Results 81 to 90 of about 182,361 (307)

Pharmacogenetics of ophthalmic topical β-blockers [PDF]

, 2008
Glaucoma is the second leading cause of blindness worldwide. The primary glaucoma risk factor is elevated intraocular pressure. Topical β-blockers are affordable and widely used to lower intraocular pressure.
Smith, Edward M., Wilke, Russell A., Sidjanin, Duska J., McCarty, Catherine A., Patchett, Richard   +4 more
core   +1 more source

Large‐scale Whole‐Exome Sequencing Defines the Protein‐Coding Architecture of Retinal Structure, Visual Function, and Major Blinding Diseases

Advanced Science, EarlyView.
Large‐scale whole‐exome sequencing in 356,982 UK Biobank participants defines the protein‐coding architecture of retinal structure, visual function, and major blinding diseases. Pleiotropic genes, including CFI, C3, and RIOX1, bridge multiple retinal phenotypes, while experimental validation of FYB2 implicates RPE barrier dysfunction, providing ...
Jianqing Li, Yijun Ge, Jingxiao Du, Liu Yang, Bangsheng Wu, Chenyue Hang, Mengxi Shen, Yimin Mao, Ting Zhang, Qiyu Bo, Tianyuan Zhao, Yutian Jiao, Yazhi Wang, Shunxiang Gao, Jieqiong Chen, Junran Sun, Tong Li, Huixun Jia, Yang Dou, Wei Cheng, Xiaoling Wan, Jintai Yu, Xiaodong Sun, Bai Lu   +23 more
wiley   +1 more source

Long-term efficacy of combined phacoemulsification and Hydrus microstent in open-angle glaucoma versus combined-mechanism/primary angle closure glaucoma: a retrospective cohort study

BMC Ophthalmology
Background Compare the efficacy of combined Hydrus-cataract surgery in open angle glaucoma (OAG) to combined mechanism glaucoma (CMG) and primary angle closure glaucoma (PACG) over 36 months.
Kelly C. Nguyen, Eden Ng, Sunee Chansangpetch, Sunita Radhakrishnan, Ngoc Nguyen, Andrew G. Iwach, Shan Lin   +6 more
doaj   +1 more source

Morphology of corneal nerves using Confocal Microscopy ( Confoscan 3) in the open angle glaucoma” [PDF]

, 2005
Morphology of corneal nerves using Confocal Microscopy ( Confoscan 3) in the open angle ...
DONATI S., ARRICO, Loredana, PUCCI R, ACCONCIA M.C., MASCARO T.   +4 more
core  

A Blood‐Derived Factor Rescues ALS: Platelet Factor 4 Activates OPTN‐Dependent Autophagy to Clear SOD1 Aggregates Independently of PINK1

Advanced Science, EarlyView.
Systemic platelet factor 4 (PF4) is significantly depleted in amyotrophic lateral sclerosis (ALS). Peripheral PF4 replenishment restores central proteostasis by driving OPTN‐dependent, PINK1‐independent selective autophagy in motor neurons. This intervention effectively clears toxic SOD1 aggregates, blunts glial activation, and preserves neuromuscular ...
Qingjian Xie, Yanbo Zhu, Wenhua Jiang, Haobo Xie, Yaojia Li, Mengjie Hu, Kezheng Li, Huan Yu, Yixuan Pan, Chaoyi Jiang, Xueqin Song, Dongsheng Fan, Binbin Deng   +12 more
wiley   +1 more source

Evaluation of LOXL1 gene polymorphisms in exfoliation syndrome and exfoliation glaucoma [PDF]

, 2008
Purpose: To evaluate genetic susceptibility of lysyl oxidase-like 1 (LOXL1) gene polymorphisms to exfoliation syndrome (XFS) and exfoliation glaucoma (XFG) in a case-control cohort of American and European patients.
Spiteri, Anthony, Tarkkanen, A, Sarfarazi, M, O\u27Brien, Colm, Ritch, Robert, Tarkkanen, Ahti, Child, AH, Aragon-Martin, JA, Spiteri, A, Liebmann, Jeffrey, Liebmann, J, Cobb, CJ, Blaaow, Karima, Mercieca, Franco, Mercieca, F, Damji, KF, O'Brien, C, Blaaow, K, Rezaie, T, Cobb, Caroline J, Damji, Karim F, Ritch, R, Aragon-Martin, Jose A   +22 more
core  

A genome-wide association study of intra-ocular pressure suggests a novel association in the gene FAM125B in the TwinsUK cohort [PDF]

, 2014
Glaucoma is a major cause of blindness in the world. To date, common genetic variants associated with glaucoma only explain a small proportion of its heritability. We performed a genome-wide association study of intra-ocular pressure (IOP), an underlying
Aung, T., van Koolwijk, L.M., Tanja, Z., Khor, C.-C., Venturini, C., Mackey, D.A., Jonas, J.B., Hammond, C., Vitart, V., Viswanathan, A.C., Hewitt, A.W., Gibson, J., Klaver, C.C., Nag, A., WTCCC, None, Xu, L., Lemij, H.G., Liao, J., Wang, J.J., Mitchell, P., Young, T. L., Macgregor, S., Ramdas, W.D., Vithana, E., Hofman, A., Lu, Y., Small, K.S., Wojciechowski, R., van Duijn, C.M., Hysi, P.G., Springelkamp, H., Yonova-Doing, E., Fleck, B.W., Williams, K.M., Wong, T.-Y., Uitterlinden, A.G., Lotery, A.J., Cheng, C.-Y., Tai, E.-S., Hohn, R., Teo, Y.-Y., Vingerling, J.R.   +41 more
core   +1 more source

From Flexible to Conformable Pressure Sensors: Mechanisms, Materials, and Biomedical Applications

Advanced Electronic Materials, EarlyView.
This review highlights recent progress, challenges and future opportunities in pressure sensing for advanced biomedical applications. We summarize key transduction mechanisms and emerging material strategies, discuss representative wearable and implantable applications for continuous physiological monitoring and provide a focused perspective on barrier
Rishabh B. Mishra, Andrea Ottomaniello, Virgilio Mattoli   +2 more
wiley   +1 more source

Surveillance for ocular hypertension : an evidence synthesis and economic evaluation [PDF]

, 2012
OBJECTIVES: To determine effective and efficient monitoring criteria for ocular hypertension [raised intraocular pressure (IOP)] through (i) identification and validation of glaucoma risk prediction models; and (ii) development of models to determine ...
Banister, K, Burr, JM, Kotecha, A, Garway-Heath, D., H Lemij, M Ryan, Tuulonen, A., Vale, L., Fraser, C., R Sanders, Crabb, D, Kotecha, A., Cook, J, Y Takwoingi, S Vernon, Takwoingi, Y., Banister, K., Fraser, C, Deeks, J, Sanders, R, A Tuulonen, Cook, J., Hernández, R, Glasziou, P, Tuulonen, A, Lemij, H., Vale, L, Burr, Jennifer Margaret, Elders, A., Burr, J.M., R Asaoka, Takwoingi, Y; id_orcid, Azuara-Blanco, A, P Glasziou, Botello-Pinzon, P, Garway-Heath, D, Ryan, Mandy, Vazquez-Montes, M, Lemij, H, Deeks, J., Takwoingi, Y, D Crabb, Azuara-Blanco, A.; id_orcid, L Vale, A Azuara-Blanco, Perera, R., Ryan, M, van der Schoot, J, Perera, R, Sanders, R., Crabb, D., Elders, A, D Garway-Heath, Ryan, M., R Hernández, K Banister, C Fraser, J Cook, J van der Schoot, Botello-Pinzon, P., A Elders, A Kotecha, Glasziou, P., Azuara-Blanco, A., King, A., J Deeks, JM Burr, A King, Burr, J M, Glasziou, Paul, King, A, Vernon, S, Asaoka, R., Vazquez-Montes, M., van der Schoot, J., Vernon, S., M Vazquez-Montes, Perera, Rafael, R Perera, Asaoka, R, Hernandez, R., P Botello-Pinzon   +81 more
core   +1 more source

Diabetic Retinopathy Classification With Convolutional Neural Networks Designed by the Fuzzy Grey Wolf Optimizer With Parameter Adaptation

AI &Innovation, EarlyView.
ABSTRACT The detection and classification of diseases have become a field of interest for artificial intelligence in recent years, where the development of methods and models that allow support for specialists in different health fields has allowed early detection of diseases and the provision of timely treatment to patients.
Rodrigo Cordero‐Martínez, Daniela Sánchez, Patricia Melin   +2 more
wiley   +1 more source