Results 101 to 110 of about 36,434 (282)

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

The Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu, Xiao‐Bo Wan, Yong‐Shun Liang, Tian Lan, Hao Liang   +4 more
wiley   +1 more source

The Pattern and Severity of Primary Glaucoma in Qatar

Qatar Medical Journal, 2002
Purpose: To describe the pattern of both types of pri-mary glaucoma in Qatari adult patients and to outline the main problem related to its management. Material and Methods: A random sample of Qatari patients with primary glaucoma either open angle or angle closure glaucoma in whom the diagnosis was made after the age of 30 years was ...
openaire   +1 more source

Corneal Hysteresis and Rates of Neuroretinal Rim Change in Glaucoma

, 2022
Purpose: To evaluate the impact of corneal hysteresis (CH) as a risk factor for progressive neuroretinal rim loss in glaucoma, as measured by spectral-domain OCT of the Bruch's membrane opening minimum rim width (MRW).Design: Prospective, observational ...
Jammal, Alessandro A., Medeiros, Felipe A.   +1 more
core   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

Med Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen, Chunrun Qu, Zeyu Wang, Jinglin Zhou, Hongwei Liu, Yingjie Li, Bowei Liu, Hao Zhang, Nan Zhang, Jingwei Zhang, Quan Cheng   +10 more
wiley   +1 more source

Pattern of RNFL Damage in Early- and Late-Stage Primary Open-Angle Glaucoma Using the Disc Damage Likelihood Scale and Optical Coherence Tomography

Türk Oftalmoloji Dergisi
Objectives: To determine patterns of peripapillary retinal nerve fiber layer (RNFL) damage in early- and late-stage glaucoma based on the Disc Damage Likelihood Scale (DDLS).
Noor UlAin, Rehan Moinuddin Shaikh, Tayyaba Gul Malik   +2 more
doaj   +1 more source

Adaptation of the steady-state PERG in early glaucoma

, 2014
Previous studies have shown that the onset of high-contrast, fast reversing patterned stimuli induces rapid blood flow increase in retinal vessels in association with slow changes of the steady-state pattern electroretinogram (PERG) signal. We tested the
Porciatti, Vittorio, Shif, Olga A, Bosse, Brandon, Feuer, William J, Parekh, Prashant K, Ventura, Lori M   +5 more
core   +1 more source

Audio‐guided exercise at home: Preliminary findings from a pilot study on physical activity for people with low vision

PM&R, EarlyView.
Abstract Background: Individuals with severe visual impairments frequently refrain from regular physical activity due to multiple barriers, including transportation difficulties, financial constraints, and limited availability of exercise programs tailored to their needs. These factors often contribute to a gradual decline in mobility and independence.
Luca Correale, Monica Schmid, Francesco Decortes, Luca Martinis, Giulia Liberali, Luca Bandirali, Gabriella Cusella, Cristina Montomoli   +7 more
wiley   +1 more source

Severe open angle glaucoma in hereditary hemorrhagic telangiectasia

Clinical Case Reports, 2015
Key clinical messageHereditary hemorrhagic telangiectasia (HHT) is an autosomal dominant disease. Conjunctival telangiectasias and retinal vascular malformations are known ocular manifestations. We report here the first case of open angle glaucoma in a patient with HHT caused by a nonsense mutation, C471X in the ACVRL1 gene.
Kuchtey, Rachel W, Naratadam, George T, Kuchtey, John   +2 more
openaire   +2 more sources

Detecting Glaucoma Progression Using Guided Progression Analysis with OCT and Visual Field Assessment in Eyes Classified by International Classification of Disease Severity Codes

, 2019
To compare the detection and rates of progressive retinal nerve fiber layer (RNFL) and ganglion cell-inner plexiform layer (GCIPL) loss with spectral-domain (SD) OCT and visual field (VF) loss using Guided Progression Analysis (GPA; Carl Zeiss Meditec ...
Feuer, William J, Nguyen, Alexander T, Greenfield, David S, Lee, Jennifer, Bhakta, Amitabha S   +4 more
core   +1 more source

An Age‐Friendly Approach to Caring for Chronic Lung Disease in the Ambulatory Setting

Respirology, EarlyView.
ABSTRACT Many common chronic lung diseases, such as chronic obstructive pulmonary disease (COPD) and interstitial lung disease (ILD), have much greater prevalence among older adults and as a result, pose a substantial burden of morbidity, disability, and mortality. The care of older adults with chronic lung disease necessitates an age‐friendly approach
Angela O. Suen, Lauren R. Pollack, C. Adrian Austin, Leah J. Witt   +3 more
wiley   +1 more source