Results 81 to 90 of about 35,176 (249)

Spatial multi‐omics unveils sphingolipid metabolic reprogramming within the retinal pathological niche

open access: yesiMeta, EarlyView.
Spatial multi‐omics of the mouse ocular globe after retinal ischemia‐reperfusion (RIR) injury identifies the ganglion cell layer (GCL) as an immunometabolic niche where Trem2+ microglia closely associate with stressed retinal ganglion cells (RGCs) through Trem2‐Apoe signaling.
Yunhong Shi   +12 more
wiley   +1 more source

A retrospective study of the association between Fuchs’ endothelial dystrophy and glaucoma

open access: yesClinical Ophthalmology, 2014
Greg D Rice,1 Kristin Wright,1 Steven M Silverstein2 1Kansas City University of Medicine and Biosciences, Kansas City, MO, USA; 2Silverstein Eye Centers, Kansas City, MO, USA Objective: The goal of this study was to examine a possible clinical ...
Rice GD, Wright K, Silverstein SM
doaj  

The regulation of stem cell fate and its application in neural regeneration

open access: yesInterdisciplinary Medicine, EarlyView.
Regulating stem cell fate is crucial for neural regeneration. This review summarizes key physical, biological, and chemical strategies and their applications in repairing nerve injuries, providing new insights for regenerative medicine. Abstract Regulating the fate of stem cells (SCs) is a key technical problem in the field of regenerative medicine and
Yuexin He   +3 more
wiley   +1 more source

Pattern of RNFL Damage in Early- and Late-Stage Primary Open-Angle Glaucoma Using the Disc Damage Likelihood Scale and Optical Coherence Tomography

open access: yesTürk Oftalmoloji Dergisi
Objectives: To determine patterns of peripapillary retinal nerve fiber layer (RNFL) damage in early- and late-stage glaucoma based on the Disc Damage Likelihood Scale (DDLS).
Noor UlAin   +2 more
doaj   +1 more source

Optic Nerve Thickness Assessed by Ocular Ultrasonography in Obstructive Sleep Apnea

open access: yesJournal of Ultrasound in Medicine, EarlyView.
Objectives Obstructive sleep apnea (OSA) has been associated with various ocular complications, yet ultrasonographic evaluation of optic nerve thickness and its relationship with nocturnal hypoxemia remains poorly understood. This study aimed to evaluate optic nerve thickness and globe dimensions using ocular ultrasonography in patients with different ...
Buğra Kerget   +4 more
wiley   +1 more source

Correlation of Average RNFL Thickness Using the STRATUS OCT with the Perimetric Staging of Glaucoma

open access: yesPhilippine Journal of Ophthalmology, 2012
Objective: To determine the correlation between average peripapillary retinal nerve fiber layer (RNFL) thickness measured with time domain optical coherence tomography (TD-OCT) in normal and glaucoma eyes. Methods: This was a cross-sectional study of
Sharah Mae G. Kaw, MD   +3 more
doaj  

Assessment of Treatment Response in Patients With Scleromyxedema by the Double Modified Rodnan Skin Score

open access: yesJEADV Clinical Practice, EarlyView.
ABSTRACT Background Scleromyxedema (SMX) is a cutaneous mucinosis characterised by an abnormal accumulation of mucin in the skin and limited treatment options. Assessment of therapy response during treatment is challenging. Objectives Patients with SMX receiving high‐dose intravenous IVIg therapy were included to assess validity of the double modified ...
Julia K. Winkler, Alexander H. Enk
wiley   +1 more source

Prone Positioning–Associated Anisocoria: A Diagnostic Pitfall in Critical Care

open access: yes
Eye &ENT Research, EarlyView.
Saim Mahmood Khan   +5 more
wiley   +1 more source

LPCAT3 as a Potential Drug Target for Ultraviolet Radiation–Induced Cataract: Insights From Multiomics Analysis

open access: yesThe Kaohsiung Journal of Medical Sciences, EarlyView.
ABSTRACT Ultraviolet B (UVB) radiation is a major risk factor for cataract development, but the molecular mechanisms underlying this process, particularly the involvement of regulated cell death pathways such as ferroptosis, remain unclear. Transcriptomic, proteomic, and metabolomic analyses were performed on lens tissues from UVB‐induced cataract rat ...
Fei Xu   +4 more
wiley   +1 more source

Mapping Causal Biology: Mendelian Randomization in the Era of Big Data

open access: yesMed Research, EarlyView.
Mendelian randomization (MR) leverages genetic variants to mitigate confounding biases in causal inference. This review systematically maps MR's methodological evolution, highlights its expanding applications in epidemiology and drug target validation, and outlines future directions for overcoming current biases through dynamic, multi‐omics, and cross ...
Xuanlu Shen   +10 more
wiley   +1 more source

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