Zhongguo shiyan zhenduanxue, 2020 目的探讨长链非编码RNA(lncRNA)脑胞质RNA1(BCYRN1)在前列腺癌中的表达及作用机制。方法选取前列腺癌组织及癌旁正常组织、前列腺癌细胞(PC-3、22RV1、DU-145、LNcap)及前列腺正常肌成纤维基质细胞(WPMY-1),采用qRT-PCR检测BCYRN1表达,分析BCYRN1表达与临床病理特征的关系。选取前列腺癌细胞,分别转染siRNA-NC和siRNA-BCYRN1,CCK8法检测细胞增殖活性,流式细胞仪检测细胞凋亡,Western blot法检测凋亡相关蛋白表达。结果 ...
刘明 +6 more
doaj
KHSRP regulates the responsiveness of prostate cancer cells to androgens through ANK3 [PDF]
Objective·To investigate the impact of KH-type splicing regulatory protein (KHSRP) on the proliferation of prostate cancer cells and the regulation of downstream gene expression, and explore the potential role and mechanism of KHSRP in the transition of ...
CAI Renjie, XU Ming
core +1 more source
Infant Mental Health Journal: Infancy and Early Childhood, Volume 46, Issue 2, Page 215-227, March 2025.Abstract There are considerable data documenting the importance of early experiences for healthy human development. Though widely accepted amongst mental health clinicians, developmental researchers and early childhood policymakers, this information is not well known by much of the public.
Sarah Hinshaw +5 more
wiley +1 more source
Evaluation of short⁃term efficacy of precision immunotherapy in prostate cancer patients and construction of a personalized prediction model based on PD⁃L1/TMB [PDF]
Objective To evaluate the short⁃term efficacy of programmed death⁃ligand 1（PD⁃L1）inhibitors in patients with prostate cancer and to construct an individualized predictive model based on PD⁃L1 expression levels and tumor mutational burden（TMB）to predict ...
HUANG Yiming，CHEN Zhibin，LYU Tianbing，LI Xiaorong
core +2 more sources
Integrated single-cell and transcriptome sequencing to construct a prognostic model of M2 macrophage-related genes in prostate cancer [PDF]
ObjectiveTo explore the prognostic value of M2 macrophage-related genes in prostate cancer (PCa), aiming to predict tumor prognosis more accurately and enable personalized treatment.Methods·RNA sequencing (RNA-seq) data of PCa were downloaded from The ...
FENG Chengling, HAN Bangmin, TANG Kairan
core +1 more source
Expert consensus of 177Lu-labeled PSMA radioligand therapy for clinical practice of prostate cancer (2024 edition) [PDF]
177Lu-labeled prostate-specific membrane antigen radioligand therapy (177Lu-PSMA-RLT) is an innovative treatment approach that precisely delivers β radiation emitted by 177Lu to prostate cancer cells, causing radiation damage to the tumor cells’ DNA and ...
Cancer Nuclear Medicine Committee of China Anti-Cancer Association, Chinese Association of Nuclear Medicine Physicians
core +1 more source
Zhongguo shiyan zhenduanxue, 2018 目的检测不同分期前列腺癌组织中AKR1C3的表达,分析AKR1C3表达水平与前列腺癌进展之间的关系。方法收集46例人前列腺良性增生及前列腺癌穿刺组织样本,免疫组织化学染色方法检测AKR1C3的表达,以Gleason评分分析AKR1C3表达平与前列腺癌进程的关系。结果在正常前列腺上皮、和良性前列腺增生组织内AKR1C3呈低表达,在前列腺癌组织内随着Gleason评分的升高,AKR1C3表达逐渐升高。结论 AKR1C3的表达水平与Gleason评分呈正相关性,提示AKR1C3可作为评价前列腺癌恶性程度的指标。
李倩, 赵刚, 阚秀芳
doaj
Application Value of Transperineal Biopsy Using Electromagnetic Needle Tracking Combined with Rapid Paraffin-Embedded Section of Small Specimen in Diagnosis of Prostate Cancer [PDF]
ObjectiveTo explore the application value of mpMRI-TRUS multi-modal image fusion transperineal biopsy technique using electromagnetic needle tracking under local anesthesia combined with rapid paraffin-embedded section of small specimen in the diagnosis ...
Qiang LU +4 more
core +1 more source
Heterogeneous nuclear ribonucleoprotein H1 and its function in tumor development and metastasis [PDF]
Heterogeneous nuclear ribonucleoprotein (hnRNP) and heterogeneous nuclear RNA (hnRNA) form complexes that regulate RNA splicing and transportation. hnRNPH1 is a member of the hnRNP family of proteins and plays an important role in physiological processes,
FAN Zhisong, FENG Li, ZHANG Zongwen
core +1 more source
Innovations and Challenges in Molecular Probe-Based Precision Theranostics for Genitourinary System Tumors [PDF]
Genitourinary system tumors, as a major clinical challenge posing a serious threat to human health, urgently require breakthroughs in the construction of a precision diagnosis and treatment system.
Mingwei SUN, Pengyu GUO, Wanhai XU
core +1 more source