生育酚结合蛋白通过磷酸肌醇3激酶途径抑制前列腺癌的生长 [PDF]
, 2007 【目的】探讨生育酚结合蛋白（TAP）对前列腺癌细胞的生长调节及其分子机制。【方法】四甲基偶氮唑盐生长试验（MTY）测定细胞增殖情况，体外集落形成试验测定各细胞的致癌能力，高效液相层析法检测细胞内维生素E的浓度，利用基因转染、基因沉默、免疫印迹、Northem blot，RT-PCR、荧光定量PCR、免疫沉淀等方法研究TAP对前列腺细胞生长的作用及机制。【结果】TAPmRNA水平在前列腺癌细胞LNCaP、PC-3、DU-145、CWR22R中均较正常前列腺细胞RWPE-1低 ...
周祥福 +7 more
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The application of artificial intelligence in medical clinics, scientific research and education [PDF]
In recent years, artificial intelligence (AI) has developed rapidly, and clinical medicine has also seen revolutionary changes. This study traces the development process of AI in clinical medicine and conducts an in-depth analysis through specific ...
Diyuan QIN +12 more
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AGR2: A New Biomarker of Cancer Diagnosis [PDF]
, 2013 Agr2(AnTErIOr grAdIEnT-2)是一种分泌蛋白,广泛存在于前列腺、乳腺、肺和胰腺等腺体组织,并在这些腺体的肿瘤组织过量表达,与肿瘤细胞的存活、生长和转移相关。临床上,Agr2的表达与乳腺癌、前列腺癌、胰腺癌等癌症的发展和预后相关,被认为是一个很有前途的早期诊断和判定预后的标志性基因。该文就目前Agr2的研究现状,尤其是肿瘤相关的功能、机制和临床调查上的最新研究进展加以综述。AGR2 is a secreted protein and widely found in the ...
吕忠显 +3 more
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[Predictive model of early urinary continence recovery based on prostate gland MRI parameters after laparoscopic radical prostatectomy]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2023 Mao H +8 more
europepmc +1 more source
Research hotspots of prostate cancer at the international conferences on urology in 2022. [PDF]
Zhejiang Da Xue Xue Bao Yi Xue Ban, 2023 Yi J, Li J, Xie L.
europepmc +1 more source
基于GEO数据库发现促前列腺癌转移基因SERPINE1及其临床意义
, 2018 目的分析上皮间质转换(EMT)相关基因在前列腺癌肿瘤细胞转移前后的变化,并筛选有潜在研究价值的基因,研究其临床价值,并初步探索其可能的分子机制。方法通过EMT通路的聚合酶链式反应(PCR)芯片分析两种具有不同转移能力的前列腺癌细胞表达差异,并结合GSE16560、Kaplan-Meier、Oncomine及基因探针富集分析(GSEA)数据库筛选潜在研究对象及相关通路。结果丝氨酸蛋白酶抑制蛋白E1(SERPINE1)表达与前列腺癌中较高的Gleason评分正相关(6分vs.7分,P=0.003 2 ...
孙慧敏, 岳俊涛, 邵晨, 雷志杰
core
[Application of dynamic contrast enhanced status in multiparametric magnetic resonance imaging for prostatic cancer with PI-RADS 4 lesion]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2023 Yuan CW +6 more
europepmc +1 more source
[Bipolar androgen therapy followed by immune checkpoint inhibitors in metastatic castration resistant prostate cancer: A report of 4 cases]. [PDF]
Beijing Da Xue Xue Bao Yi Xue Ban, 2022 Liu SJ +6 more
europepmc +1 more source
Prediction of pelvic lymph node metastasis in prostate cancer using radiomics based on T2-weighted imaging. [PDF]
Zhong Nan Da Xue Xue Bao Yi Xue Ban, 2022 Liu X +5 more
europepmc +1 more source
[Research progress on prostate-specific membrane antigen ligand positron emission tomography imaging of prostate cancer]. [PDF]
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi, 2022 Li Y, Liu B, Yuan Y, Qin W.
europepmc +1 more source