Results 81 to 90 of about 40,094 (247)

pH/ROS‐Responsive Injectable Hydrogel Co‐Loaded with B7‐H3 Blocker and NETs Suppressor Boosts OSCC Synergistic Immunotherapy

Advanced Science, EarlyView.
A pH/ROS‐dual‐responsive injectable hydrogel, formed by dynamic boronic ester and Schiff base crosslinking, co‐delivers enoblituzumab (B7‐H3 blocker) and Cl‐amidine (NETs suppressor). Via localized intratumoral delivery, it synergistically reprograms the immunosuppressive tumor microenvironment, overcomes T cell infiltration barriers, restores ...
Huan Li, Yun Li, Yating Hu, Yanbing Yao, Yaodong He, Jing Li, Jiaqi Tang, Zhenyan Zhao, Yan Wang, Yulun He, Xiaolong Zhang, Xinjie Yang, Jianhua Wei   +12 more
wiley   +1 more source

Design and Simulation Analysis of Lower Limit Follow-up Mechanism of Submerged Glider Based on the Parallel Four-bar Linkage

Jixie chuandong, 2023
The wave glider is a new type of unmanned observation platform on water surface, which can generate forward thrust by obtaining wave energy through the swing of submerged glider's hydrofoils.
Liu Fen, Zhang Jin, Sang Hongqiang, Sun Xiujun, Yang Shiming   +4 more
doaj  

Preliminary study of tug-glider freight systems utilizing a Boeing 747 as the tug [PDF]

Performance of the tug-glider system was severely limited by ground run. In most cases studied, additional engines were necessary. Except at short ranges for which additional payload were carried in the tow plane, the productivity of the basic aircraft ...
Foss, W. E., Jr., Heyson, H. H.
core   +1 more source

Analytical and scale model research aimed at improved hangglider design [PDF]

, 1979
Research consisted of a theoretical analysis which attempts to predict aerodynamic characteristics using lifting surface theory and finite-element structural analysis as well as an experimental investigation using 1/5 scale elastically similar models in ...
Chang, L. S., Kroo, I.
core   +1 more source

A framework for the local information dynamics of distributed computation in complex systems

, 2013
The nature of distributed computation has often been described in terms of the component operations of universal computation: information storage, transfer and modification.
A. Wuensche, A.S. Klyubin, A.S. Klyubin, C.G. Langton, C.R. Shalizi, C.R. Shalizi, D.E. Edmundson, D.J.C. MacKay, D.P. Feldman, F. Takens, G.J. Martinez, H. Gutowitz, J. Boedecker, J. Pahle, J.A. Brown, J.E. Hanson, J.E. Hanson, J.H. Conway, J.J. Atick, J.L. Casti, J.P. Crutchfield, J.P. Crutchfield, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, J.T. Lizier, K. Lindgren, K. Lindgren, K.I. Goh, L. Gray, M. Cook, M. Mitchell, M. Mitchell, M. Prokopenko, M. Prokopenko, M. Prokopenko, M. Wibral, M.A. Sánchez-Montañés, M.H. Jakubowski, M.H. Jakubowski, N. Boccara, O. Kinouchi, P. Grassberger, P. Grassberger, P. Grassberger, P. Grassberger, R. Badii, R. Morgado, R.M. Fano, S. Wolfram, S. Wolfram, S. Wolfram, S. Wolfram, T. Helvik, T. Schreiber, W. Bialek, W. Hordijk   +62 more
core   +1 more source

Helix Alignment, Chevrons, and Edge Dislocations in Twist‐Bend Ferroelectric Nematics

Advanced Science, EarlyView.
The recently discovered twist‐bend ferroelectric nematic (NTBF) is the new member of the multiferroic family, representing a fluid with an oblique helicoidal (heliconical) periodic structure of spontaneous electric polarization. The work presents a thorough exploration of the material properties of this phase, how the periodic modulation of ...
Bijaya Basnet, Priyanka Kumari, Sathyanarayana Paladugu, Damian Pociecha, Jakub Karcz, Przemysław Kula, Nataša Vaupotič, Ewa Górecka, Oleg D Lavrentovich   +8 more
wiley   +1 more source

ZBTB21 Is a Dual Suppressor of Pyroptosis and MHC‐I Antigen Presentation That Promotes Tumor Immune Evasion

Advanced Science, EarlyView.
ZBTB21 is a transcription factor that epigenetically suppresses pyroptosis and MHC‐I antigen presentation, enabling tumor immune evasion. Genetic ablation of ZBTB21 activates pyroptotic cell death and enhances antigen presentation, recruiting CD8+ T cells to overcome immune checkpoint blockade resistance.
Lei Zhao, Linlin Sheng, Jianhao Qiu, Junjie Ma, Kai Jin, Binggong Zhao, Tianrun Miao, Jing Chen, Yehong Li, Zhan Zhang, Dongfeng Sun, Yongmeng Li, Hui Tian   +12 more
wiley   +1 more source

Optimal trajectory generation in ocean flows [PDF]

, 2004
In this paper it is shown that Lagrangian Coherent Structures (LCS) are useful in determining near optimal trajectories for autonomous underwater gliders in a dynamic ocean environment.
Inanc, Tamer, Marsden, Jerrold E., Shadden, Shawn C.   +2 more
core   +1 more source

Multimodal AI‐Driven Identification of Dehydrocostus Lactone as a Potent Renal Fibrosis Attenuator Targeting IQGAP1

Advanced Science, EarlyView.
Renal fibrosis, a hallmark of CKD, lacks effective treatments. Herein, we developed a multimodal AI model (TCM‐SPred) to identify anti‐fibrotic agents and found that dehydrocostus lactone (DCL) targets IQGAP1 to inhibit Wnt signaling, blocking the interaction between IQGAP1 and CCT3, demonstrating potent anti‐fibrotic activity in vitro and in vivo ...
Weijiang Lin, Wenzhuo Xu, Kang Liu, Ping Wang, Zhenzhen Zhu, Wenyu Lu, Zhe Zheng, Xiaoqian Peng, Xunkai Yin, Shulan Mei, An Pan, Jian Liu, Lihong Hu   +12 more
wiley   +1 more source

Experimental application of gliders communication system in South China Sea

Frontiers in Communications and Networks
Utilizing the motion characteristics of underwater gliders, a water acoustic communication system based on heterogeneous gliders was designed. The system consists of a surface wave glider and an acoustic underwater glider, which are respectively equipped
Shuyang Jia, Shuyang Jia, Shuyang Jia, Baoheng Liu, Baoheng Liu, Sichen Zou, Xiaochuan Zhang, Xiaochuan Zhang, Xiaochuan Zhang   +8 more
doaj   +1 more source