Results 141 to 150 of about 222,357 (321)

Partial purification and biochemical characterization of a T cell suppressor factor produced by human glioblastoma cells. [PDF]

, 1985
Martin Schwyzer, A. Fontana
openalex   +1 more source

Tumor Microenvironment On‐A‐Chip and Single‐Cell Analysis Reveal Synergistic Stromal–Immune Crosstalk on Breast Cancer Progression

Advanced Science, EarlyView.
Using a 3D tumor microenvironment (TME)‐on‐a‐chip model, tumor–stromal–immune crosstalk in triple‐negative breast cancer is studied, revealing the TME's combinatorial effect on cancer progression. Integrating single‐cell transcriptomic analysis demonstrates metabolic reprogramming via the kynurenine pathway, highlighting the complex TME cellular ...
Kalpana Ravi, Yining Zhang, Lydia Sakala, Twinkle Jina Minette Manoharan, Barbara Pockaj, Joshua LaBaer, Jin G. Park, Mehdi Nikkhah   +7 more
wiley   +1 more source

Postoperative glioblastoma segmentation: Development of a fully automated pipeline using deep convolutional neural networks and comparison with currently available models [PDF]

arXiv
Accurately assessing tumor removal is paramount in the management of glioblastoma. We developed a pipeline using MRI scans and neural networks to segment tumor subregions and the surgical cavity in postoperative images. Our model excels in accurately classifying the extent of resection, offering a valuable tool for clinicians in assessing treatment ...
arxiv  

Patient age, histologic features, and length of survival in patients with glioblastoma multiforme [PDF]

, 1987
Peter C. Burger, Sylvan B. Green
openalex   +1 more source

Accumulation of Damaging Lipids in the Arf1‐Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia

Advanced Science, EarlyView.
Arf1 defects activate the AKT‐mTORC1‐SREBP1‐FASN pathway to increase lipid synthesis and disrupt ER‐mitochondrial‐lysosomal homeostasis in neurons. Impaired mitochondria secrete damaged mtDNA via mitochondria‐derived extracellular vesicles, which is phagocytosed by the microglia and activated inflammation signaling.
Xu Li, Shuhan Jin, Danke Wang, Ying Wu, Xiaoyu Tang, Yufan Liu, Tiange Yao, Shoufa Han, Lin Sun, Yuetong Wang, Steven X. Hou   +10 more
wiley   +1 more source

Cadherin‐6 is a novel mediator for the migration of mesenchymal stem cells to glioblastoma cells in response to stromal cell‐derived factor‐1

FEBS Open Bio
Glioblastoma recruits various nontransformed cells from distant tissues. Although bone marrow‐derived mesenchymal stem cells (MSCs) have been observed migrating to glioblastoma, the underlying mechanism driving MSC migration toward glioblastoma remains ...
Aran Park, Seung‐Eun Kim, Jinyeong Yu, Donghyun Son, Kyung‐Sup Kim, Eunjin Koh, Ki‐Sook Park   +6 more
doaj   +1 more source

Simplified model of immunotherapy for glioblastoma multiforme: cancer stem cells hypothesis perspective [PDF]

arXiv
Despite ongoing efforts in cancer research, a fully effective treatment for glioblastoma multiforme (GBM) is still unknown. Since adoptive cell transfer immunotherapy is one of the potential cure candidates, efforts have been made to assess its effectiveness using mathematical modeling.
arxiv  

Intramedullary spinal cord astrocytoma versus glioblastoma. The prognostic importance of histologic grade [PDF]

, 1982
Gene Kopelson, Rita M. Linggood
openalex   +1 more source

Therapeutic Delivery of circDYM by Perillyl Alcohol Nanoemulsion Alleviates LPS‐Induced Depressive‐Like Behaviors

Advanced Science, EarlyView.
PANEs are specifically designed to enhance the brain delivery efficiency of circDYM compared to commercialized lipid nanoparticles (LNPs). Intranasal administration of PANE‐circDYM effectively alleviated LPS‐induced depressive‐like behaviors by mitigating neuroinflammation and promoting neuroplasticity.
Feng Gao, Zhongkun Zhang, Minzi Ju, Liang Bian, Huijuan Wang, Sibo Zhao, Ningbo Cai, Yu Wang, Yanpeng Jia, Ling Shen, Yuan Zhang, Honghong Yao   +11 more
wiley   +1 more source

Ferroptosis-Related Transcriptional Level Changes and the Role of CIRBP in Glioblastoma Cells Ferroptosis

Biomedicines
Background/Objective: We aimed to elucidate the roles of ferroptosis-associated differentially expressed genes (DEGs) in glioblastoma and provide a comprehensive resource for researchers in the field of glioblastoma cell ferroptosis. Methods: We used RNA
Zijiang Yang, Ting Zhang, Xuanlin Zhu, Xiaobiao Zhang   +3 more
doaj   +1 more source