Results 171 to 180 of about 263,515 (247)

A Supramolecular Nanoscavengers: Based “Cargo‐Exchange” Breaking Cholesterol Metabolic Dysregulation for Glioblastoma Therapy

Advanced Science, EarlyView.
Dysregulated cholesterol metabolism, driven by a complex array of mechanisms, is a defining characteristic of glioblastoma (GBM). In this study, supramolecular nanoscavengers are engineered by harnessing the intrinsic binding affinity between endogenous small‐molecule cholesterol and β‐cyclodextrin (β‐CD).
Zonghua Tian, Yun Chen, Jingyi Zhou, Shilin Zhang, Hongrui Fan, Xuwen Li, Tao Sun, Chen Jiang   +7 more
wiley   +1 more source

Frontal glioblastoma masquerading as schizophrenia exacerbation. [PDF]

Oxf Med Case Reports
Peng F, Koh WY, Lee CY.
europepmc   +1 more source

ACTR-61. A RANDOMIZED PHASE 2 TRIAL OF CEDIRANIB IN COMBINATION WITH OLAPARIB VERSUS BEVACIZUMAB IN PATIENTS WITH RECURRENT GLIOBLASTOMA [PDF]

, 2019
Isabel Arrillaga‐Romany, Solmaz Sahebjam, David Picconi, Jian Campian, Pierre Giglio, Jan Drappatz, Robert Aiken, John L. Villano, Eudocia Q. Lee, Mary Welch, Benjamin M. Ellingson, Douglas Ney, Kevin Becker, Alona Muzikansky, Biswajit Das, Elizabeth M. Swisher, Andrew B. Nixon, Chris Karlovich, P. Mickey Williams, S. Percy Ivy, Tracy T. Batchelor, Elizabeth R. Gerstner   +21 more
openalex   +1 more source

Targeting DAP5 Disrupts Alternate Mode of Translational Initiation in Tregs and Potentiates Antitumor Immunity

Advanced Science, EarlyView.
Regulatory T cells (Tregs) suppress antitumor immunity. This study identifies that the translation scaffold DAP5/eIF4G2 is upregulated in tumor‐infiltrating Tregs (ti‐Tregs). DAP5 mediates an alternate translation mode to sustain CD25 and MCL‐1 expression, which is critical for ti‐Treg stability and survival in the tumor microenvironment.
Xiaojiang Lai, Guihong Pan, Xixi Feng, Jun Zhang, Yunxia Li, Shanmeizi Zhao, Zhenming Lin, Yun Feng, Wei Bao, Hongyan Yang, Chengmei Xie, Chen Huang, Jun Wang   +12 more
wiley   +1 more source

Interferon-gamma signaling pathway: Modulation of key genes in the progression of glioblastoma. [PDF]

World J Biol Chem
Oropeza-Martínez E, Palacios Serrato EG, Zamora-Salas SX, Lira-Rodríguez NA, López-Mignon SH, Martinez-Benitez MB, Tecalco-Cruz AC.   +6 more
europepmc   +1 more source

RND3 promotes Snail 1 protein degradation and inhibits glioblastoma cell migration and invasion

, 2016
Baohui Liu, Huimin Dong, Xi Lin, Xiangsheng Yang, Xiaojing Yue, Jian Yang, Yuntao Li, Liquan Wu, Xiaonan Zhu, Shenqi Zhang, Daofeng Tian, Junmin Wang, Qiang Cai, Shanping Mao, Qianxue Chen, Jiang Chang   +15 more
openalex   +2 more sources

CBIO-10. GLIOBLASTOMA RECURRENCE CORRELATES WITH INCREASED APE1 AND AN IMMUNE-SUPPRESSION MICROENVIRONMENT [PDF]

, 2017
Amanda L. Hudson, Nicole Parker, Peter Khong, Jonathon Parkinson, Rowan J. Ikin, Ying Zhu, Helen Wheeler, Viive M. Howell   +7 more
openalex   +1 more source

T Cell Exhaustion in Cancer Immunotherapy: Heterogeneity, Mechanisms, and Therapeutic Opportunities

Advanced Science, EarlyView.
T cell exhaustion limits immunotherapy efficacy. This article delineates its progression from stem‐like to terminally exhausted states, governed by persistent antigen, transcription factors, epigenetics, and metabolism. It maps the exhaustion landscape in the TME and proposes integrated reversal strategies, providing a translational roadmap to overcome
Yang Yu, Xiaoyu Yao, Qingyang Wang, Mengrui Yang, Runze Li, Jiangjiang Qin, Jing Zhuang, Changgang Sun   +7 more
wiley   +1 more source

Intracranial primary collision tumours: A comprehensive systematic review on preoperative radiological accuracy and neuro-oncological insights. [PDF]

Brain Spine
Jadoon S, Solou M, Moussa AA, Zisakis A.
europepmc   +1 more source

Hammerhead Ribozyme against γ-Glutamylcysteine Synthetase Attenuates Resistance to Ionizing Radiation and Cisplatin in Human T98G Glioblastoma Cells

, 2005
政治 谷
openalex   +1 more source