Results 321 to 330 of about 319,103 (346)
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Critical Reviews in Oncology/Hematology, 2008
Glioblastoma (GBM) is the most malignant among astrocytic tumours and is associated with a poor prognosis. Age, performance status, mini-mental status examination score, methylation status of methylguanine methyltransferase promoter and extent of surgery constitute the main prognostic factors.
Brandes AA +5 more
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Glioblastoma (GBM) is the most malignant among astrocytic tumours and is associated with a poor prognosis. Age, performance status, mini-mental status examination score, methylation status of methylguanine methyltransferase promoter and extent of surgery constitute the main prognostic factors.
Brandes AA +5 more
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Surgical Neurology, 1987
There are very few recorded instances of brain tumors with ipsilateral secondary brain atrophy. All 10 cases in the literature are from Japan. We report a case of primary cerebral hemiatrophy with ipsilateral glioblastoma. As far as we are aware, no such case has been described in the literature.
V.K. Jain +3 more
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There are very few recorded instances of brain tumors with ipsilateral secondary brain atrophy. All 10 cases in the literature are from Japan. We report a case of primary cerebral hemiatrophy with ipsilateral glioblastoma. As far as we are aware, no such case has been described in the literature.
V.K. Jain +3 more
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Journal of Neurosurgery, 1981
✓ The results of a second operation for tumor removal in 24 adult patients with supratentorial glioblastoma multiforme or anaplastic astrocytoma were analyzed. The median survival time after reoperation was 14 weeks. Five of the 24 patients lived 6 months or longer after reoperation. Only three of these patients maintained a Karnofsky rating (KR) of at
Phillip A. Tibbs +8 more
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✓ The results of a second operation for tumor removal in 24 adult patients with supratentorial glioblastoma multiforme or anaplastic astrocytoma were analyzed. The median survival time after reoperation was 14 weeks. Five of the 24 patients lived 6 months or longer after reoperation. Only three of these patients maintained a Karnofsky rating (KR) of at
Phillip A. Tibbs +8 more
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Immunomodulation for glioblastoma
Current Opinion in Neurology, 2017Purpose of review Immunotherapy has emerged as a cornerstone of modern oncology with regulatory approvals for a variety of immunotherapeutics being achieved for a spectrum of cancer indications. Nonetheless the role of these approaches for patients with glioblastoma (GBM), the most common and deadliest primary malignant brain ...
John H. Sampson +3 more
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World Neurosurgery, 2018
Glioblastoma evades conventional therapies through a variety of mechanisms, including suppression of the immune system. This immunosuppressive microenvironment provides a potential target for treatment. There are several immunotherapies being actively investigated, including inhibition of immune checkpoint regulators, development of antitumor ...
Jessica A. Wilcox +2 more
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Glioblastoma evades conventional therapies through a variety of mechanisms, including suppression of the immune system. This immunosuppressive microenvironment provides a potential target for treatment. There are several immunotherapies being actively investigated, including inhibition of immune checkpoint regulators, development of antitumor ...
Jessica A. Wilcox +2 more
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Pediatric Pathology, 1985
Both morphologic and clinical features of 72 consecutive cases of brain tumors, collected over 9 years at Le Bonheur Children's Medical Center, were reviewed. We identified 11 cases as glioblastoma, representing 16% of all intracranial neoplasm and 26% of glial tumors. The patients ranged in age from 1 to 15 years with the median age of 10 years. There
Suk-Jung Koh +2 more
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Both morphologic and clinical features of 72 consecutive cases of brain tumors, collected over 9 years at Le Bonheur Children's Medical Center, were reviewed. We identified 11 cases as glioblastoma, representing 16% of all intracranial neoplasm and 26% of glial tumors. The patients ranged in age from 1 to 15 years with the median age of 10 years. There
Suk-Jung Koh +2 more
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Acta Oncologica, 2009
Glioblastomas are considered fast-growing tumors, but there is little information on their growth kinetics prior to diagnosis.
Hofer, S, Kollias, S, Weller, M
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Glioblastomas are considered fast-growing tumors, but there is little information on their growth kinetics prior to diagnosis.
Hofer, S, Kollias, S, Weller, M
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Journal of Neurosurgery, 2001
OBJECT The extent of tumor resection that should be undertaken in patients with glioblastoma multiforme (GBM) remains controversial. The purpose of this study was to identify significant independent predictors of survival in these patients and to ...
M. Lacroix +13 more
semanticscholar +1 more source
OBJECT The extent of tumor resection that should be undertaken in patients with glioblastoma multiforme (GBM) remains controversial. The purpose of this study was to identify significant independent predictors of survival in these patients and to ...
M. Lacroix +13 more
semanticscholar +1 more source
Expert Opinion on Pharmacotherapy, 2007
Glioblastoma multiforme (GBM) are among the most devastating neoplasms claiming the lives of patients within a median of 1 year after diagnosis. Treatment of GBM requires a multidisciplinary approach. Treatments include surgery, radiotherapy, chemotherapy and so on. Temozolomide (TMZ) has emerged as an active agent against malignant gliomas.
Tomokazu Aoki +2 more
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Glioblastoma multiforme (GBM) are among the most devastating neoplasms claiming the lives of patients within a median of 1 year after diagnosis. Treatment of GBM requires a multidisciplinary approach. Treatments include surgery, radiotherapy, chemotherapy and so on. Temozolomide (TMZ) has emerged as an active agent against malignant gliomas.
Tomokazu Aoki +2 more
openaire +3 more sources
Current Treatment Options in Neurology, 2008
Patients with newly diagnosed glioblastoma multiforme should undergo a maximal tumor resection and then, whenever possible, should be entered into a clinical trial. The current standard of care consists of external beam irradiation, to a total of 60 Gy over 6 weeks, in combination with low-dose daily temozolomide, followed by at least six cycles of ...
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Patients with newly diagnosed glioblastoma multiforme should undergo a maximal tumor resection and then, whenever possible, should be entered into a clinical trial. The current standard of care consists of external beam irradiation, to a total of 60 Gy over 6 weeks, in combination with low-dose daily temozolomide, followed by at least six cycles of ...
openaire +3 more sources