Results 71 to 80 of about 4,624,933 (258)

One size does not fit all: An in vitro evaluation of the effects of bezafibrate and medroxyprogesterone acetate on human SH‐SY5Y and U‐87 MG cancer cells

FEBS Open Bio, EarlyView.
Drugs previously repurposed to target blood cancers reduced neuroblastoma and glioblastoma cell growth and viability. However, their levels of anticancer activity were different and their clinical application may be problematic due to side effects at effective doses.
Abhishek Kharawatkar, Francesco Michelangeli, Farhat Latif Khanim, Christopher Martin Bunce, William Eustace Basil Johnson   +4 more
wiley   +1 more source

Receptors for hyaluronic acid and poliovirus: a combinatorial role in glioma invasion? [PDF]

, 2012
BACKGROUND: CD44 has long been associated with glioma invasion while, more recently, CD155 has been implicated in playing a similar role. Notably, these two receptors have been shown closely positioned on monocytes.
James R Smith, Zaynah Maherally, Geoffrey J Pilkington, Maherally, Zaynah, Qian An, Pilkington, Geoff, An Qian, Pilkington Geoffrey J., An, Qian, Smith James R., Smith, James, Maherally Zaynah   +11 more
core   +2 more sources

Chromobox protein homolog 7 suppresses the stem-like phenotype of glioblastoma cells by regulating the myosin heavy chain 9-NF-κB signaling pathway

Cell Death Discovery
Cancer stem cells (CSCs) are significant factors in the treatment resistance and recurrence of glioblastoma. Chromobox protein homolog 7 (CBX7) can inhibit the progression of various tumors, but its impact on the stem cell-like properties of glioblastoma
Kaixiang Ni, Yuankun Liu, Pinggang DI, Lu Wang, Hui Huang, R. M. Damian Holsinger, Karrie Mei-Yee Kiang, Jiantong Jiao   +7 more
doaj   +1 more source

UiO‐66 metal–organic frameworks in biomedicine: From structural tunability to bioimaging, photodiagnostics, and photodynamic cancer therapy

FEBS Open Bio, EarlyView.
UiO‐66(Zr) metal–organic frameworks are chemically stable, biocompatible, and highly tunable nanomaterials. Their modular structure enables controlled drug delivery, multimodal bioimaging, and light‐activated photodynamic therapy, supporting integrated diagnostic and therapeutic (theranostic) applications in cancer and biomedical research.
Veronika Huntošová, Grigorii Rakhalskii, Miroslav Almáši   +2 more
wiley   +1 more source

Alkaloids of fascaplysin are promising chemotherapeutic agents for the treatment of glioblastoma: Review

, 2020
Glioblastoma is one of the most aggressive human brain tumors. Even following all the modern protocols of complex treatment, the median patient survival typically does not exceed 15 months.
Valeriia Gulaia, Piatkova, Mariia,, Khotimchenko, Rodion,, Sharma, Aruna,, Mikhail Shmelev, Gulaia, Valeriia,, Bryukhovetskiy, Igor,, Andrey Bryukhovetskiy, Lyakhova, Irina,, Rodion Khotimchenko, Mariia Piatkova, Hari Shanker Sharma, Romanishin, Aleksandr,, Aruna Sharma, Igor Bryukhovetskiy, Bryukhovetskiy, Andrey,, Irina Lyakhova, Aleksandr Romanishin, Shmelev, Mikhail,, Sharma, Hari Shanker,   +19 more
core   +1 more source

Small-Molecule XIAP Inhibitors Enhance γ-Irradiation-Induced Apoptosis in Glioblastoma

Neoplasia: An International Journal for Oncology Research, 2009
Because evasion of apoptosis can cause radioresistance of glioblastoma, there is a need to design rational strategies that counter apoptosis resistance.
Sri Hari Krishna Vellanki, Andreas Grabrucker, Stefan Liebau, Christian Proepper, Adriana Eramo, Veit Braun, Tobias Boeckers, Klaus-Michael Debatin, Simone Fulda   +8 more
doaj   +1 more source

A New Pathway Promotes Adaptation of Human Glioblastoma Cells to Glucose Starvation

Cells, 2020
Adaptation of glioblastoma to caloric restriction induces compensatory changes in tumor metabolism that are incompletely known. Here we show that in human glioblastoma cells maintained in exhausted medium, SHC adaptor protein 3 (SHC3) increases due to ...
Alberto Azzalin, Francesca Brambilla, Eloisa Arbustini, Katia Basello, Attilio Speciani, Pierluigi Mauri, Paola Bezzi, Lorenzo Magrassi   +7 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Avaliação in vitro do efeito citotóxico de chalconas sintéticas em glioblastoma multiforme humano [PDF]

, 2014
Dissertação (mestrado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas, Programa de Pós-graduação em Biologia Celular e do Desenvolvimento.
Bittencourt, Lucas Felipe Fernandes
core  

O-methylguanine-DNA methyltransferase (MGMT) mRNA expression predicts outcome in malignant glioma independent of MGMT promoter methylation [PDF]

, 2011
Background: We analyzed prospectively whether MGMT (O(6)-methylguanine-DNA methyltransferase) mRNA expression gains prognostic/predictive impact independent of MGMT promoter methylation in malignant glioma patients undergoing radiotherapy with ...
Kreth Simone, Friedrich W. Kreth, Hans A Kretzschmar, Lutz Juergen, Ludwig C. Hinske, Friedrich W Kreth, Ledderose Carola, Kretzschmar, Hans A., Kreth, Friedrich-Wilhelm, Juergen Lutz, Eigenbrod, Sabina, Kreth, Simone, Tonn, Joerg C., Thon Niklas, Thon, Niklas, Eigenbrod Sabina, Joerg C Tonn, Hinske, Ludwig C., Egensperger Rupert, Kretzschmar Hans A., Carola Ledderose, Rupert Egensperger, Kreth Friedrich W., Joerg C. Tonn, Lutz, Juergen, Niklas Thon, Hans A. Kretzschmar, Kreth, Friedrich W., Egensperger, Rupert, Hinske Ludwig C., Hinske, Ludwig Christian, Ludwig C Hinske, Sabina Eigenbrod, Tonn Joerg C., Ledderose, Carola, Simone Kreth   +35 more
core   +1 more source