Results 231 to 240 of about 352,265 (309)

LAPTM5-dependent lipophagy enhances ferroptosis sensitivity in glioma cells. [PDF]

Transl Cancer Res
Zhang Y, Lu L, Zhao Q, Ma A, Jin M, Wang X, Yang Y, Meng X, Sun Y, Zheng J, Zheng X.   +10 more
europepmc   +1 more source

SUMOylation regulates tumorigenesis and progression: Molecular mechanisms and therapeutic applications

Interdisciplinary Medicine, EarlyView.
SUMOylation, a dynamic post‐translational modification, acts as a master regulator at the heart of tumor malignancy. Our work delineates how the SUMOylation cycle—mediated by E1/E2/E3 enzymes and reversed by SENPs—orchestrates multiple hallmarks of cancer. The central pathway converges on three critical pathological axes: 1.
Yimao Wu, Zichang Chen, Yinting Hu, Gokhan Zengin, Qian Zhang, Meng‐Yao Li, Wenlong Sun   +6 more
wiley   +1 more source

Natural killer cell dysfunction in glioma: from immune evasion to immunotherapy. [PDF]

Front Immunol
Zhang R, Ma P, Tang K, Cao Y, Yang Y, Hao S, Li T, Peng X.   +7 more
europepmc   +1 more source

Synthesis and Characterization of Juglone‐Derived cu (II), Mn (II) and Zn (II) Complexes and Investigation of Their Cytotoxic Activities Against Lung and Colon Cancer Cells in Vitro and in Silico

Journal of Applied Toxicology, EarlyView.
ABSTRACT Three new Zn (II), Cu (II) and Mn (II) complexes have been synthesized from 5‐hydroxy‐1,4‐naphthoquinone (HNQ). Elemental analysis, magnetic susceptibility, UV–Vis, IR and Mass spectrometry have all been used to explore the structural characterization of these compounds.
Mustafa Öztatlıcı, Turan Birimoğlu, Semih Güler, Rukiye Betül Çolaksel, Mehmet Tahir Husunet, Mehmet Sönmez   +5 more
wiley   +1 more source

Lipid-associated macrophage remodeling is present in the tumor microenvironment after high-grade glioma recurrence. [PDF]

IBRO Neurosci Rep
Xie G, Cai H, Zuo F, Tian S, Zhang H, Fang C, Xiao J, Wan J.   +7 more
europepmc   +1 more source

Formulation‐Dependent Cytotoxic Effects of Commercial and Analytical‐Grade Mancozeb in C6 Glial Cells

Journal of Applied Toxicology, EarlyView.
ABSTRACT Mancozeb (MZ) is a widely used dithiocarbamate fungicide composed of manganese (Mn) and zinc (Zn) complexes. Increasing concern has been raised regarding its occupational and human health relevance, particularly due to its neurotoxic potential associated with Mn‐related cellular dysfunction.
Lavínia Lazzarotti, Felipe Vanz, Karina Giacomini Varela, Viviane Glaser, Diego de Carvalho, Aline Pertile Remor   +5 more
wiley   +1 more source

<i>MSTN</i> and <i>TCF12</i> as Candidate Immunometabolic Signatures in Glioma-Associated Foam Cells: Insights from Integrated Multi-Omics Analysis. [PDF]

Curr Issues Mol Biol
Liu X, Song Z, Sun Z, Liu C, Kang X, Qiao H, Tu X, Li T, Fu Z, Wang Y.   +9 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source

Detection of IDH1.R132H mutant protein in plasma extracellular vesicles and its application in preoperative noninvasive precision diagnosis of glioma. [PDF]

BMC Cancer
Liu M, Zhao K, Yang C, Sun G, Wu D, Yang Y, Xu B.   +6 more
europepmc   +1 more source

A Comparative Study of IVIM‐MRI Fitting Techniques in Glioma Grading: Conventional, Bayesian, and Voxel‐Wise and Spatially‐Aware Deep Learning Approaches

Journal of Magnetic Resonance Imaging, EarlyView.
ABSTRACT Background Intravoxel incoherent motion (IVIM) analysis of diffusion‐weighted MRI (DWI) provides microvascular perfusion and diffusion information. However, parameter estimation is limited by noise sensitivity, variability across fitting methods, and lack of standardization.
Misha P. T. Kaandorp, Andras Jakab, Christian Federau, Peter T. While   +3 more
wiley   +1 more source