Results 341 to 350 of about 536,830 (388)

Precision therapies for genetic epilepsies in 2025: Promises and pitfalls

Epilepsia Open, EarlyView.
Abstract By targeting the underlying etiology, precision therapies offer an exciting paradigm shift to improve the stagnant outcomes of drug‐resistant epilepsies, including developmental and epileptic encephalopathies. Unlike conventional antiseizure medications (ASMs) which only treat the symptoms (seizures) but have no effect on the underlying ...
Shuyu Wang, Emilio Perucca, Samuel F. Berkovic, Piero Perucca   +3 more
wiley   +1 more source

Role of lysine acetylation-related genes in the diagnosis and prognosis of glioma. [PDF]

Sci Rep
Zhou M, Wang B, Liang R, Luan X.
europepmc   +1 more source

NIR II‐Guided Photoactivatable Silencing Polyplex Boosts Cancer Immunotherapy

Exploration, EarlyView.
Due to limitation of penetration therapy with first and second‐generation photodynamic therapy (PDT) photosensitizers, an NIR II‐guided photoactivatable complex was proposed via the self‐assembly of the photosensitive polymer PTSQ and the electrostatic adsorption of siPD‐L1 to enhance cancer immunotherapy.
Yuquan Zhang, Jie Wang, Tian Zhang, Dongsheng Tang, Haiyin Yang, Shuai Guo, Yuchuan Fan, Caixia Sun, Haihua Xiao, Yuanyu Huang, Yuhua Weng   +10 more
wiley   +1 more source

Characterization of lysine crotonylation-related lncRNAs for prognostic assessment and immune response in glioma. [PDF]

Front Pharmacol
Song M, Xu J, Gui Z, Wu Y, Wang F, Sheng H, Huang X, Qian J, Qin H, Wang Y.   +9 more
europepmc   +1 more source

Deciphering the Potential Causal and Prognostic Relationships Between Gut Microbiota and Brain Tumors: Insights from Genetics Analysis and Machine Learning

Exploration, EarlyView.
The causal relationship between gut microbiota and brain tumors and potential prognostic value of microbiota are still unclear. This study confirmed the causal effects of specific gut microbiota on three common brain tumors and identified microbe‐related genes that are expressed in brain tissue and correlated with the abundance of gut microbiota ...
Changwu Wu, Fushu Luo, Yongye Zhu, Chunbo Liu, Zheng Chen, Xiangyu Wang, Jun Tan, Qing Liu   +7 more
wiley   +1 more source

Expression profile and prognostic relevance of immune infiltration-related RBMS1 in gliomas: a multidimensional integrative analysis. [PDF]

J Cancer Res Clin Oncol
Zhang Y, Zhou Y, Zhang S, Zhou L.
europepmc   +1 more source

Emerging Target Discovery Strategies Drive the Decoding of Therapeutic Power of Natural Products and Further Drug Development: A Case Study of Celastrol

Exploration, EarlyView.
Using celastrol as a case study, this review summarizes various target discovery strategies for natural products, including chemical proteomics, protein microarray, degradation‐based protein profiling, proteome‐wide label‐free approaches, network pharmacology, target‐based drug screening, and indirect strategies.
Yanbei Tu, Guiyu Dai, Yanyan Chen, Lihua Tan, Hanqing Liu, Meiwan Chen   +5 more
wiley   +1 more source

Bibliometric and visualization analysis of glioma pharmacotherapy from 2020 to 2024. [PDF]

Front Neurol
Hong X, Wei Z, Zuo T, Xu L, Zhang H, Xu T, Wang D, Lu C, Hou L.   +8 more
europepmc   +1 more source

Integrative analysis of crotonylation-associated genes reveals prognostic and therapeutic targets in gliomas. [PDF]

Front Oncol
Yin B, Fan Z, Yu P, Li J, Wang Y, Shu M.
europepmc   +1 more source

Sex-specific glioma genome-wide association study identifies new risk locus at 3p21.31 in females, and finds sex-differences in risk at 8q24.21 [PDF]

, 2018
Rubin, Joshua B.
core   +1 more source