Results 31 to 40 of about 12,335,014 (292)

Structural and mechanistic basis for the regulation of the chloroplast signal recognition particle by (p)ppGpp

open access: yesFEBS Letters, EarlyView.
LHCPs are transported to the thylakoid membrane via the (cp)SRP pathway. This process involves a transit complex of (cp)SRP43, (cp)SRP54 and LHCP, which interacts with (cp)FtsY and Alb3 at the membrane. GTP hydrolysis by (cp)SRP54 and (cp)FtsY triggers complex dissociation.
Victor Zegarra   +7 more
wiley   +1 more source

The multiple roles of the NlpC_P60 peptidase family in mycobacteria – an underexplored target for antimicrobial drug discovery

open access: yesFEBS Letters, EarlyView.
The NlpC_P60 superfamily of peptidases is recognised by its key role in bacterial cell wall homeostasis. Recently, studies have also described the involvement of NlpC_P60‐like enzymes in bacterial competitive mechanisms and pathogenesis across several lineages.
Catharina dos Santos Silva   +1 more
wiley   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Unraveling Mycobacterium tuberculosis acid resistance and pH homeostasis mechanisms

open access: yesFEBS Letters, EarlyView.
Mycobacterium tuberculosis exhibits a remarkable resilience to acid stress. In this Review, we discuss some of the molecular mechanisms and metabolic pathways used by the tubercle bacilli to adapt and resist host‐mediated acid stress. Mycobacterium tuberculosis (Mtb) is a successful pathogen that has developed a variety of strategies to survive and ...
Janïs Laudouze   +3 more
wiley   +1 more source

Vacuumless topological defects in Lyra geometry [PDF]

open access: yesAstrophys.Space Sci.319:169-175,2009, 2009
Few years ago, Cho and Vilenkin have proposed that topological defects can arise in symmetry breaking models without having degenerate vacua. These types of defects are known as vacuumless defects. In the present work, the gravitational field of a vacuumless global string and global monopole have been investigated in the context of Lyra geometry.
arxiv   +1 more source

Unconventional mRNA processing and degradation pathways for the polycistronic yrzI (spyTA) mRNA in Bacillus subtilis

open access: yesFEBS Letters, EarlyView.
The S1025 peptide is the major antidote to the YrzI toxin, which we renamed here as SpyT (Small Peptide YrzI Toxin) and SpyA (Small Peptide YrzI Antitoxin) (1). Degradation of the toxin–antitoxin spyTA mRNA, either by a translation‐dependent cleavage by the endoribonuclease Rae1 (2) or by direct attack by 3′‐exoribonucleases (3), also contributes to ...
Laetitia Gilet   +4 more
wiley   +1 more source

Globally subanalytic arc-symmetric sets [PDF]

open access: yesarXiv, 2023
We show that a globally subanalytic set can be realized as the image of a semianalytic set by a finite composite of global blowings-up. As an application, we prove that a globally subanalytic arc-symmetric set of pure dimension is the image under such a composite of a real analytic manifold of the same dimension, and derive basic geometric properties ...
arxiv  

The gravitational field of a global monopole [PDF]

open access: yesClass.Quant.Grav.8:761-767,1991, 2009
We present an exact solution to the non-linear equation which describes a global monopole in the flat space. We re-examine the metric and the geodesics outside the global monopole. We will see that a global monopole produces a repulsive gravitational field outside the core in addition to a solid angular deficit.
arxiv   +1 more source

The solution supramolecular structure of α2 → 8 polysialic acid suggests a structural cause for its low immunogenicity

open access: yesFEBS Letters, EarlyView.
α2 → 8 polysialic acid elicits poor immunogenicity. Small‐angle scattering shows a supramolecular structure with parallel‐chain binding, although in different forms at μm and mm calcium. The major histocompatibility complex requires molecular weights around 2000 Da to produce antibodies, and 2000 Da polysialic oligomers will bind in these structures ...
Kenneth A. Rubinson
wiley   +1 more source

Nacionalismos deportivos con “clase”: el rugby argentino en la era profesional/global

open access: yesAntípoda: Revista de Antropología y Arqueología, 2018
Men’s rugby in Buenos Aires is going through a phase of professionalization and globalization which is blurring the long-standing link between that sport and the upper-middle and upper classes of the city.
Sebastián Fuentes, Daniel Guinness
doaj   +1 more source

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