Results 71 to 80 of about 4,491,703 (310)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Six decades of global crop yield increase and cropland expansion from 1960 to 2020

open access: yesEnvironmental Research Communications
Population growth, changing consumption preferences, technological advances, globalised trade and environmental influences have all shaped global agriculture.
Karina Winkler   +3 more
doaj   +1 more source

Global prevalence and antibiotic resistance profiles of carbapenem-resistant Pseudomonas aeruginosa reported from 2014 to 2024: a systematic review and meta-analysis

open access: yesFrontiers in Microbiology
IntroductionCarbapenem-resistant Pseudomonas aeruginosa (CRPA) represents a global threat, but the global distribution of carbapenem resistant bacteria remains a critical issue in public health.MethodsWe conducted a systematic review and meta-analysis on
Tsepo Ramatla   +6 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Global burden and trends of self-harm from 1990 to 2021, with predictions to 2050

open access: yesFrontiers in Public Health
BackgroundSelf-harm has become a major public health problem globally. Data on the burden of self-harm in this study were taken from the GBD 2021. This study aimed to quantify historical trends (1990–2021) in the global burden of self-harm across genders,
Li Xie   +4 more
doaj   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Satellite Clear‐Sky Observations Overestimate Surface Urban Heat Islands in Humid Cities

open access: yesGeophysical Research Letters
Satellite‐based thermal infrared (TIR) land surface temperature (LST) is hindered by cloud cover and is applicable solely under clear‐sky conditions for estimating surface urban heat island intensity (SUHII).
Qiquan Yang   +9 more
doaj   +1 more source

Home - About - Disclaimer - Privacy