Results 71 to 80 of about 1,441 (286)

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Global attractivity in a logistic difference model with a feedback control [PDF]

, 2002
Sufficient conditions are obtained for the global attractivity of the positive equilibrium of a logistic difference model with a feedback ...
Liao, Liusheng, Yu, Jianshe, Wang, Lin
core   +1 more source

Global attractivity without stability for Liénard type systems

International Journal of Mathematics and Mathematical Sciences, 2001
We are concerned with some conditions such as the trivial solution of a planar system of differential equations (including the Liénard system) that is globally attractive but not stable.
Marian Mureşan
doaj   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Comparative Effectiveness and Safety of Inebilizumab Versus Rituximab in AQP4‐IgG‐Positive NMOSD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Rituximab (anti‐CD20, RTX) and inebilizumab (anti‐CD19, INE) represent B‐cell‐depleting therapies used for aquaporin‐4 antibody‐positive (AQP4‐IgG+) neuromyelitis optica spectrum disorder (NMOSD); however, direct comparative evidence remains limited.
Jie Lin, Binbin Xue, Dewei Xie, Jia Li, Juyuan Pan, Lanbing Zhu, Qiaowen Tong, Jing Lin, Ruofan Zhu, Xu Zhang, Junhui Xia, Xiang Li   +11 more
wiley   +1 more source

Dynamic behavior of the discrete amensalism model with density dependent birth rate and nonselective harvesting in partial closure

上海师范大学学报. 自然科学版
Discrete amensalism model with density dependent birth rate and nonselective harvesting in partial closure is proposed in this paper. Using the iteration scheme and the comparison principle of difference equations, a set of necessary criteria for the ...
XU Lili, LEI Chaoquan, XUE Yalong
doaj   +1 more source

Partial Extinction, Permanence, and Global Attractivity in Nonautonomous n-Species Gilpin-Ayala Competitive Systems with Impulses

Discrete Dynamics in Nature and Society, 2012
The qualitative properties of general nonautonomous n-species Gilpin-Ayala competitive systems with impulsive effects are studied. Some new criteria on the permanence, extinction, and global attractivity of partial species are established by using the ...
Juan Hou, Hanhui Liu
doaj   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Oscillation and global attractivity in a nonlinear delay periodic model of respiratory dynamics [PDF]

, 2002
In this paper, we shall consider the nonlinear delay differential equation where m and n are positive integers, and V(t) and λ(t) are positive periodic functions of period ω.
Saker, S.H., S.H. Saker, S. Agarwal, Agarwal, S.   +3 more
core   +1 more source