Results 31 to 40 of about 6,539 (268)

Global Attractor for Doubly Nonlinear Parabolic Equation [PDF]

ISRN Applied Mathematics, 2012
Our aim in this paper is to study the long-time behavior for a class of doubly nonlinear parabolic equations. First we show that the problem has a unique solution. Then we prove that the semigroup corresponding to the problem is norm-to-weak continuous in Lq and H01. Finally we establish the existence of global attractor of the problem in Lq and H01.
Li, Yongjun, Wang, Suyun, Zhang, Yanhong
openaire   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

FEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo, Carolin Ector, Hanspeter Herzel   +2 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Global attractor for the Cahn-Hilliard system [PDF]

Bulletin of the Australian Mathematical Society, 1994
The Cahn-Hilliard system, a natural extension of the single Cahn-Hilliard equation in the case of multicomponent alloys, will be shown to generate a dissipative semigroup on the phase space ℋ = [H2(Ω)]m. Following Hale's ideas and based on the existence and form of the Lyapunov functional, our main result will be the existence of a global attractor on ...
Cholewa, Jan W., Dlotko, Tomasz
openaire   +2 more sources

Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions

FEBS Letters, EarlyView.
We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva, Puspa Kunwar, Md Ibnul Rifat Rahman, Joanna Koryo Kwao, Nathan Lehman, Zihan Zhang, Trenton Paul, Claire Cheng, Nicholas Truex, Hui‐Ting Lee, Jun Zhang   +10 more
wiley   +1 more source

Global Attractors and Asymptotic Gain Property for Non-Autonomous Inclusion of Reaction–Diffusion Type

Journal of Optimization, Differential Equations and Their Applications
We investigate global resolvability and stability of attractors for parabolic inclusion with multi-valued interaction function of reaction-diffusion type and non-autonomous disturbances.
Oleksiy V. Kapustyan, Taras V. Yusypiv, M. Ospanov, M. Alday   +3 more
doaj   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

About the Structure of Attractors for a Nonlocal Chafee-Infante Problem

Mathematics, 2021
In this paper, we study the structure of the global attractor for the multivalued semiflow generated by a nonlocal reaction-diffusion equation in which we cannot guarantee the uniqueness of the Cauchy problem.
Rubén Caballero, Alexandre N. Carvalho, Pedro Marín-Rubio, José Valero   +3 more
doaj   +1 more source

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source