Results 21 to 30 of about 6,420 (267)
FEBS Letters, EarlyView.Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman +2 more
wiley +1 more source
Global Attraction to Solitary Waves in Models Based on the Klein-Gordon Equation
Symmetry, Integrability and Geometry: Methods and Applications, 2008 We review recent results on global attractors of U(1)-invariant dispersive Hamiltonian systems. We study several models based on the Klein-Gordon equation and sketch the proof that in these models, under certain generic assumptions, the weak global ...
Andrew A. Komech, Alexander I. Komech
doaj +1 more source
Global Attractors for Semilinear Parabolic Problems Involving X-Elliptic Operators
Bruno Pini Mathematical Analysis Seminar, 2015 We consider semilinear parabolic equations involving an operator that is X-elliptic with respect to a family of vector fields X with suitable properties.
Stefanie Sonner
doaj +1 more source
Sequence determinants of RNA G‐quadruplex unfolding by Arg‐rich regions
FEBS Letters, EarlyView.We show that Arg‐rich peptides selectively unfold RNA G‐quadruplexes, but not RNA stem‐loops or DNA/RNA duplexes. This length‐dependent activity is inhibited by acidic residues and is conserved among SR and SR‐related proteins (SRSF1, SRSF3, SRSF9, U1‐70K, and U2AF1).
Naiduwadura Ivon Upekala De Silva +10 more
wiley +1 more source
Electronic Journal of Differential Equations, 2018 Under consideration is the damped semilinear wave equation $$ u_{tt}+u_t-\Delta u+u+f(u)=0 $$ in a bounded domain $\Omega$ in $\mathbb{R}^3$ subject to an acoustic boundary condition with a singular perturbation, which we term "massless acoustic ...
Joseph L. Shomberg
doaj
Upper Semicontinuity of Pullback Attractors for the 3D Nonautonomous Benjamin-Bona-Mahony Equations
The Scientific World Journal, 2014 We will study the upper semicontinuity of pullback attractors for the 3D nonautonomouss Benjamin-Bona-Mahony equations with external force perturbation terms. Under some regular assumptions, we can prove the pullback attractors 𝒜ε(t) of equation ut-Δut-
Xinguang Yang +3 more
doaj +1 more source
Entropy, 2019 Informational Structures (IS) and Informational Fields (IF) have been recently introduced to deal with a continuous dynamical systems-based approach to Integrated Information Theory (IIT). IS and IF contain all the geometrical and topological constraints
Piotr Kalita +2 more
doaj +1 more source
Cell wall target fragment discovery using a low‐cost, minimal fragment library
FEBS Letters, EarlyView.LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan +5 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
FEBS Letters, EarlyView.This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel +13 more
wiley +1 more source