Results 41 to 50 of about 23,555 (250)

Bilateral SERS‐Microneedle Patch for Co‐Diagnosis of Diabetes Mellitus and Tuberculosis Comorbidity

Advanced Science, EarlyView.
Our study introduced a U@mP@Au‐mediated bilateral SERS‐microneedle patch for analyzing glucose levels from ISF and sensitively detecting TB biomarkers from sputum, respectively. This integrated dual‐analyte detecting platform can be used for co‐diagnosis of diabetes mellitus (DM) and tuberculosis (TB) comorbidity, which was demonstrated in ex vivo ...
Xueqin Huang, Lingzhi Chen, Jing Xu, Jiaqi Yu, Shanze Chen, Huaihong Cai, Yanguang Cong, Pinghua Sun, Jiang Pi, Lang Rao, Jierong Chen, Junxia Zheng, Haibo Zhou   +12 more
wiley   +1 more source

Adipocyte Myoglobin Is a Determinant of Energy Expenditure and a Potential Target to Limit Obesity

Advanced Science, EarlyView.
Myoglobin, known as a muscle oxygen‐carrying protein, is shown to play a key role in fat cells that burn energy. Loss of myoglobin reduces the body's ability to generate heat and increases obesity risk, while restoring it improves metabolism. The study identifies myoglobin as a regulator of fat burning and a potential target to enhance energy ...
Christian Strehlau, Helen Broghammer, Claudia Gebhardt, Anne Hoffmann, Tobias Hagemann, Şeyma Midilli, Rachel S. Zimmer, Kristin Schubert, Vasiliki Karagiannakou, Anastasia Georgiadi, Mario Ost, Martin Krüger, Lisa Roth, Kerstin Krause, Nora Klöting, Maria Keller, Martin Wabitsch, Rima Nuwayhid, Roland H. Stimson, Michael Stumvoll, Matthias Blüher, Juliane Weiner, John T. Heiker   +22 more
wiley   +1 more source

CHCHD10 Mitigates Alzheimer's Disease‐Related Phenotypes in Association With Epigenetic Remodeling in Directly Reprogrammed Neurons

Advanced Science, EarlyView.
CHCHD10 loss in Alzheimer's disease is associated with mitochondrial dysfunction, epigenomic disruption, and tau pathology. Restoration of CHCHD10 shifts DNA methylation toward a non‐disease state and reduces tau and amyloid pathology, with KATNAL2 acting as a downstream effector.
Teresa M. Thomas, Ching‐Yao Yang, Kexin Zhang, Liam Wetzel, Dina Bugybayeva, Julia Ferguson, Md Mahmudul Hasan, William Samsa, Nandita Patil, Anshul Dash, Tarini Gowda, Xiongwei Zhu, Feixiong Cheng, Tian Liu   +13 more
wiley   +1 more source

How do policymakers involve citizens in advancing health? A mixed-method qualitative study in municipalities in the Netherlands

Frontiers in Public Health
IntroductionCitizen involvement in health policymaking is becoming imperative. Yet, implementing this practice in local policymaking often proves challenging.
Helene R. Voogdt-Pruis, Diederick E. Grobbee, Sanne A. E. Peters, Sanne A. E. Peters, Charisma Hehakaya, Marielle Jambroes, Kerstin Klipstein-Grobusch, Astrid Janssens   +7 more
doaj   +1 more source

The myth of the moral enhancement: Back to the future? [PDF]

Filozofija i Društvo, 2012
This text tries to shed some light on the origin of the idea of moral enhancement, on its epistemic and moral foundations. This requires a comparative analysis of similar ideas present in various trends of bioethics today - the analysis of the very ...
Mitrović Veselin
doaj   +1 more source

AI‐Based Immortality: The Ethical Advantage of the Aretai Approach

AI &Innovation, EarlyView.
ABSTRACT The convergence of artificial intelligence, digital identity technologies, and biogerontological ambitions has produced a novel set of philosophical problems that have not yet been adequately addressed within mainstream bioethical discourse. Digital life extension—encompassing AI‐generated avatars, neural data preservation, mind uploading, and
Mirko Daniel Garasic
wiley   +1 more source

“It's Not Deterministic and It Will Never Be Deterministic”: A Qualitative Study on Stakeholder Perspectives of Polygenic Risk Score Testing for Post‐Traumatic Stress Disorder

American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, EarlyView.
ABSTRACT Post‐traumatic stress disorder (PTSD) causes significant mental and physical distress, yet only a small subset of individuals exposed to trauma develop the disorder. Scientists and clinicians are still unable to predict who will get the disorder or how it will manifest.
Brandy M. Fox
wiley   +1 more source

Production of 3D printed biomodels of the canine brain for veterinary neuroanatomy teaching

Anatomical Sciences Education, EarlyView.
Abstract Teaching neuroanatomy presents multiple challenges to both students and teachers, as it is a subject with highly dense content that commonly causes the development of aversion by students, a phenomenon referred to as “neurophobia,” which has been documented in human and veterinary medicine students.
João Victor Barbosa Tenório Fireman, Antônio Chaves de Assis Neto   +1 more
wiley   +1 more source

The association of HIV status and depressive symptoms in the Ndlovu Cohort study

Scientific Reports
HIV majorly contributes to the disease burden in South Africa. Depressive symptoms are common in people living with HIV (PLHIV). Few studies compared depressive symptoms between PLHIV and those without HIV.
Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch   +9 more
doaj   +1 more source

The performance of ChatGPT and other large language models on multiple‐choice questions in biomedical disciplines: A meta‐analysis

Anatomical Sciences Education, EarlyView.
Abstract While large language models (LLMs) have shown promise as learning tools for medical education, their reported accuracy on multiple‐choice questions (MCQs) varies widely across studies, necessitating synthesis. This meta‐analysis synthesizes LLM accuracy on text‐based MCQs from biomedical disciplines and USMLE Step 1‐level content and explores ...
Colleen M. Cheverko, Volodymyr Mavrych, Olena Bolgova, Fathima Raahima Riyas Mohamed, Jennifer Westrick, Lorena Juarez, Emily Rush, Kathryn A. Solka, Alison F. Doubleday, Jessica N. Byram, Robert Becker, Victoria Gomez, Brenda K. Anak Ganeng, Leslie A. Hoffman, Victoria A. Roach, Kirsten M. Brown, Nicole DeVaul, Colleen N. Garnett, Hannah L. Herriott, Rebecca S. Lufler, Jason C. Mussell, Joy Y. Balta, Michael A. Pascoe, Jason W. Middleton, Sharon Duffy, Georgina C. Stephens, Adam B. Wilson   +26 more
wiley   +1 more source