Results 51 to 60 of about 4,998,790 (286)

Setting up mother–infant pair lactation studies with biobanking for research according to regulatory requirements

British Journal of Clinical Pharmacology, EarlyView.
Within the ConcePTION project we set out to design two mother–infant pair studies collecting breast milk and plasma from the mother and plasma from the infant (for metformin and prednisolone) in order to demonstrate the premises and conditions for investigating potential drug transfer in association with breastfeeding.
Mats Hansson, Ida Björkgren, Jenny Svedenkrans, Helena Backman, Jarl Hellman, Linda Englund‐Ögge, Mikaela Magnusson, Inger Lindström, Andrea Wutte, Erica Sundell, Pawel Baranczewski, Laura Shaughnessy   +11 more
wiley   +1 more source

Zuranolone: A case study in (regulatory) rush to judgement?

British Journal of Clinical Pharmacology, EarlyView.
Abstract Sage, in collaboration with Biogen, submitted a new drug approval for zuranolone for postpartum depression (PPD) and major depressive disorder (MDD) in December 2022. In August 2023, the US Food and Drug Administration granted approval for PPD but denied approval for MDD.
Lisa Cosgrove, Milutin Kostic, Barbara Mintzes, Gianna D'Ambrozio, Allen Shaughnessy   +4 more
wiley   +1 more source

The association of HIV status and depressive symptoms in the Ndlovu Cohort study

Scientific Reports
HIV majorly contributes to the disease burden in South Africa. Depressive symptoms are common in people living with HIV (PLHIV). Few studies compared depressive symptoms between PLHIV and those without HIV.
Li Xiang Y. den Boer, Karine Scheuermaier, Hugo A. Tempelman, Roos E. Barth, Walter L. J. M. Devillé, Roel A. Coutinho, Diederick E. Grobbee, Francois Venter, Alinda G. Vos-Seda, Kerstin Klipstein-Grobusch   +9 more
doaj   +1 more source

Embracing complexity: theory, cases and the future of bioethics [PDF]

, 2014
This paper reflects on the relationship between theory and practice in bioethics, by using various concepts drawn from debates on innovation in healthcare research—in particular debates around how best to connect up blue skies ‘basic’ research with ...
James Wilson, Wilson, J
core   +1 more source

The effect of mild and moderate hepatic impairment on the pharmacokinetics, safety and tolerability of balcinrenone

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Balcinrenone (previously AZD9977) is a novel selective non‐steroidal mineralocorticoid receptor antagonist (MRA) with a differential mechanism of action relative to approved MRAs. The aim of this trial was to assess the pharmacokinetics, safety and tolerability of balcinrenone in participants with mild and moderate hepatic impairment ...
Anna L. Eriksson, Deeyen Karsanji, Bonifride Tuyishimire, Joanna Parkinson, Maria Heijer, Tadeusz Pawlik, Judith Hartleib‐Geschwindner, Maria Leonsson‐Zachrisson, Hans Ericsson   +8 more
wiley   +1 more source

Current perspectives of Potter's global bioethics as a bridge between clinical (personalized) and public health ethics

Acta Clinica Croatica, 2015
In the context of modern scientific and technological developments in biomedicine and health care, and the potential consequences of their application on humans and the environment, Potter’s global bioethics concept resurfaces.
Iva Sorta-Bilajac Turina, Morana Brkljačić, Cecilija Grgas-Bile, Domagoj Gajski, Aleksandar Racz, Tomislav Čengić   +5 more
doaj  

Effective altruism in global health: doing better, justly

BMJ Global Health
The effective altruism (EA) movement has seen explosive growth within the last decade, resulting in the allocation of hundreds of millions of dollars in funding towards altruistic causes.
Dominic Wilkinson, Kokila Lakhoo, Ruben Ayala, Karel-Bart Celie   +3 more
doaj   +1 more source

Toward clone‐on‐a‐chip: Ethical and legal considerations for organ‐on‐a‐chip evolution

BMEMat, EarlyView.
The term “clone‐on‐a‐chip (CoC)” is introduced as a conceptual warning for personalized organ‐on‐a‐chip platforms and not to suggest technological feasibility, where a CoC ethical discussion extends beyond issues arising from the requirements for informed consent, property rights, commercialization efforts, and cell sourcing to include potentially ...
Muhammed Erkan Karabekmez, Aliakbar Ebrahimi, Hamed Ghorbanpoor, Nicole Bassous, Su Ryon Shin, Yu Shrike Zhang, Huseyin Avci   +6 more
wiley   +1 more source

Effects of Mediterranean diet, exercise, and their combination on body composition and liver outcomes in metabolic dysfunction-associated steatotic liver disease: a systematic review and meta-analysis of randomized controlled trials

BMC Medicine
Background Metabolic dysfunction-associated steatotic liver disease (MASLD) is a leading cause of liver-related morbidity and mortality. Lifestyle interventions like the Mediterranean diet (MD) and exercise are recommended for management, but the most ...
Vicente Artola Arita, Manuel Castro Cabezas, Juliana Alexandra Hernández Vargas, Silvia Juliana Trujillo-Cáceres, Nathalie Mendez Pernicone, Lara Anne Bridge, Hamidreza Raeisi-Dehkordi, Carmen A. W. Dietvorst, Ruben Dekker, Julieth Pilar Uriza-Pinzón, Mohamed Tawfik, Kirsten A. Berk, Jo Massoels, Stan Driessen, Maarten E. Tushuizen, Adriaan G. Holleboom, Diederick E. Grobbee, Oscar H. Franco, Sara Beigrezaei, GRIPonMASH Consortium   +19 more
doaj   +1 more source

Bioethics and human rights

, 2015
Bioethics and human rights face two great contemporary challenges. The first is that they have not been designed to apply to the most powerful actors causing many of the most serious problems they strive to address – supranational corporations.
Faunce, Thomas
core   +1 more source