Results 171 to 180 of about 169,062,891 (293)

Identification of (20R)‐protopanaxadiol from Panax ginseng as a novel anti‐SARS‐CoV‐2 compound

FEBS Open Bio, EarlyView.
We established a noninfectious BAC‐based SARS‐CoV‐2 replicon that enables antiviral screening under BSL‐2 conditions. Using this platform, we screened 373 food‐derived compounds and identified (20R)‐protopanaxadiol from Panax ginseng as a novel inhibitor of SARS‐CoV‐2 RNA replication, highlighting the value of safe replicon systems for antiviral ...
Midori Takeda, Natsue Maezono, Rina Uchikoshi, Nobuyuki Kato, Masanori Ikeda   +4 more
wiley   +1 more source

The burden of brain disorders in Norway: an analysis of data from the global burden of disease study 2023. [PDF]

Lancet Reg Health Eur
Stovner LJ, Skrindo Knudsen AK, Lien L, Peersen H, Gilhus NE.   +4 more
europepmc   +1 more source

In silico and in vitro exploration of a tyrosinase for biocatalytic production of catechols

FEBS Open Bio, EarlyView.
Tyrosinase from Ralstonia pseudosolanacearum is a promising biocatalyst for producing valuable catechols from monophenol substrates. This tyrosinase is uniquely suited to this due to its high monophenolase : diphenolase ratio. We combined in silico docking and in vivo kinetic characterisation of this tyrosinase with 11 industrially relevant monophenols,
James Britton, Fang Zhao, Reeta Davis, Meg Walsh, Kevin E O'Connor, David O'Connell, Tanja Narancic   +6 more
wiley   +1 more source

Global Burden of Intracerebral Hemorrhage, 1990-2021, and Projections to 2050: A Global Burden of Disease Study 2021. [PDF]

J Korean Med Sci
Kim NY, Jo Y, Yeo D, Lee S, Oh J, Kim TH, Jeong J, Kang Y, Cho H, Kang J, Rahmati M, Woo HG, Yon DK.   +12 more
europepmc   +1 more source

From patient advocacy to patient‐driven research: Building active partnerships beginning at the bench to reach the bedside

FEBS Open Bio, EarlyView.
Research is strongest when conducted alongside patients, not just about them. Patient research organizations help integrate patient perspectives into research priorities, study design, and scientific meetings, leading to meaningful patient outcomes and development of relevant therapies.
Jenica H. Kakadia, Rachel Heilmann, Maximiliano Barrientos, Laura MacNeill, Ingrid Vallee, Sarah K. Schultz, Patrick O'Donoghue, Angelica A. Moresco, Victoria M. Siu, Ilka U. Heinemann   +9 more
wiley   +1 more source

Global, Regional, and National Burden of Self-Harm and Projections to 2030: A Systematic Analysis for the Global Burden of Disease Study 2021. [PDF]

Health Sci Rep
Li J, Dai Y, Xi J, Tyrovolas S, Ngai YK, Lu Y, Yorke J, Li Y.   +7 more
europepmc   +1 more source

Avidin is evolutionarily conserved in fish but dispensable for development and resistance against Streptococcus agalactiae in zebrafish

FEBS Open Bio, EarlyView.
The presence of biotin‐binding avidin proteins in fish and their biological significance are poorly characterized. We cataloged fish avidins and demonstrate that they are widely present and evolutionarily conserved. We created avd knockout zebrafish and show that zebavidin is dispensable for development and that resistance of avd knockout embryos in ...
Anni K. Saralahti, Markus J. T. Ojanen, Mataleena Parikka, Otto Kauko, Mika Rämet, Vesa P. Hytönen   +5 more
wiley   +1 more source

Global Lip and Oral Cavity Cancer: Analysis of the 2021 Global Burden of Disease Study. [PDF]

Int Dent J
Li S, Yan T, Wang Q, Qu Q, Xu H, Xu N.
europepmc   +1 more source

Fluorination: A strategy to tune the interactions of molecules and nanoscale systems with biological matter

FEBS Open Bio, EarlyView.
This minireview explores fluorination as a key strategy to optimize therapeutic molecules and nanocarriers. By incorporating different fluorinated motifs—from single atoms to linear and branched chains—drug delivery, cellular uptake, and colloidal stability can be improved and fine‐tuned.
Martina Beccalli, Beatrice Lucia Bona, Francesca Baldelli Bombelli   +2 more
wiley   +1 more source

Burden of Dementia in Europe, 1990-2023: a systematic analysis from the Global Burden of Disease Study 2023. [PDF]

Lancet Reg Health Eur
Urso D, Nichols E, Giannoni-Luza S, Brayne C, Ray N, Logroscino G.   +5 more
europepmc   +1 more source