Results 161 to 170 of about 1,296,781 (299)

The burden of cancer in Ethiopia, 2000–2016: analysis of evidence from the Global Burden of Disease study and Global Health Estimate

Studia Medyczne, 2020
Mulugeta Shegaze, Tadele Adal, Dereje Mesfin, Tamiru Shibiru   +3 more
doaj   +1 more source

Health and nutrition: emerging and reemerging issues in developing countries [PDF]

CONTENTS: Brief 1. Overview / Rafael Flores Brief 2. The Global Burden of Disease / Alan D. Lopez Brief 3. HIV/AIDS / Anthony Barnett and Gabriel Rugalema Brief 4. Malaria / Andrea Egan Brief 5. Tuberculosis / Ariel Pablos-Mendez Brief 6.
Flores, Rafael, ed., Gillespie, Stuart, ed.   +1 more
core  

Large‐scale bidirectional arrayed genetic screens identify OXR1 and EMC4 as modifiers of αSynuclein aggregation

FEBS Open Bio, EarlyView.
Activation of the mitochondrial protein OXR1 increases pSyn129 αSynuclein aggregation by lowering ATP levels and altering mitochondrial membrane potential, particularly in response to MSA‐derived fibrils. In contrast, ablation of the ER protein EMC4 enhances autophagic flux and lysosomal clearance, broadly reducing α‐synuclein aggregates.
Sandesh Neupane, Lea Nikolić, Lorenzo Maraio, Thomas Goiran, Nathan Karpilovsky, Stefano Sellitto, Vangelis Bouris, Jiang‐An Yin, Ronald Melki, Edward A Fon, Adriano Aguzzi, Elena De Cecco   +11 more
wiley   +1 more source

Global, regional, and national burden of epilepsy, 1990-2021: a Global Burden of Disease study. [PDF]

J Glob Health
Zhao J, Chen Q, Dong J, Gao M, Ge S, Wang A.   +5 more
europepmc   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

Lay descriptions of painful temporomandibular disorders-an international consensus proposal for Global Burden of Disease estimates. [PDF]

BMC Med
Lövgren A, Liv P, Allison JR, Baad-Hansen L, Beecroft EV, Bergman S, Bijelic T, Bucci R, Böthun A, Christidis N, Colonna A, Draghici R, Drangsholt M, Durham J, Ernberg M, Giannakopoulos NN, Gonçalves DAG, Groenke B, Jusakos M, Lobbezoo F, Lua ESP, Lunecke G, Malysa A, Manfredini D, Marpaung C, Michelotti A, Moana-Filho E, Moreno B, Nilsson E, Nixdorf DR, Nykänen L, Oyarzo JF, Peck CC, Penlington C, Restrepo C, Rongo R, Schierz O, Stanisic N, Visscher CM, Wieckiewicz M, Xiong X, Xu YY, Yanez C, Häggman-Henrikson B, Svensson P.   +44 more
europepmc   +1 more source

The global burden of haematological diseases [PDF]

The Lancet Haematology, 2018
openaire   +3 more sources

Identifying gene expression signatures for risk stratification of postoperative adjuvant chemotherapy in colorectal cancer

FEBS Open Bio, EarlyView.
A novel signature integrating genome‐wide analysis with clinical factors predicts recurrence in stage II colorectal cancer and enables a new risk stratification to guide postoperative adjuvant chemotherapy. Clinical risk stratification for postoperative recurrence in patients with pathological stage II (pStage II) colorectal cancer (CRC) is essential ...
Mayuko Otomo, Keisuke Okuno, Shuichi Watanabe, Sakiko Oba, Hiroyasu Kagawa, Masanori Tokunaga, Daisuke Ban, Yusuke Kinugasa   +7 more
wiley   +1 more source

Trends and burden of tobacco use in Nepal: Insights from the Global Burden of Disease study 1990-2021. [PDF]

Tob Prev Cessat
Paudel K, Gautam K, Niroula S, Bhusal S, Wickersham JA, Sujan SH, Kc B, Adhikari TB, Shrestha R.   +8 more
europepmc   +1 more source

Derivation and characterization of retinal pigment epithelium from urine‐derived iPSCs

FEBS Open Bio, EarlyView.
Age‐related macular degeneration causes vision loss via RPE dysfunction and loss. Traditional iPSC therapies rely on invasive biopsies, limiting scalability. Here, we utilize urine‐derived stem cells as an accessible source to generate u‐iPSCs, successfully differentiated into pigmented RPE. This “Urine‐to‐Retina” platform provides a promising path for
Daniella Beiner, Hainan Zhu, Carol Christine Bosholm, Heuy‐Ching Wang, Tracy Criswell, Anthony Atala, Jian‐Xing Ma, Yuanyuan Zhang   +7 more
wiley   +1 more source