Results 141 to 150 of about 169,062,891 (293)
IMPORTANCE: Cardiovascular disease (CVD) remains the leading cause of mortality and morbidity. Compared with disease burden rates in 1990, significant reductions in Disability-Adjusted Life Years (DALYs) burden rates for CVD have been recorded.
Aminde, Leopold +7 more
core +1 more source
Epidemiology and disease burden of tuberculosis in children: a global perspective
Infection and Drug Resistance, 2014 James A Seddon,1 Delane Shingadia21Department of Paediatric Infectious Diseases, Imperial College London, London, UK; 2Department of Paediatric Infectious Diseases, Great Ormond Street Hospital, London, UKAbstract: Our understanding of the tuberculosis ...
Seddon JA, Shingadia D
doaj
Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer
Molecular Oncology, EarlyView.Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba +5 more
wiley +1 more source
The global burden of haematological diseases [PDF]
The Lancet Haematology, 2018 openaire +3 more sources
Molecular characterization of covRS mutations in M1UK Streptococcus pyogenes
FEBS Open Bio, EarlyView.Group A Streptococcus (GAS) acquires covRS mutations driving a hypervirulent bacterial state, frequently associated with invasive disease‐like necrotizing fasciitis. We demonstrate that the newly emerged M1UK GAS lineage can also acquire these mutations.
Jarrad Pritchard +12 more
wiley +1 more source
Burden of inflammatory bowel disease in Belgium, 2020
Inflammatory bowel disease (IBD) comprises digestive disorders resulting from non-infectious inflammation of the colon and gastrointestinal tract. With its global prevalence on the rise, IBD poses significant challenges to healthcare systems.
R. Claerman +3 more
core +1 more source
Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells
FEBS Open Bio, EarlyView.Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim +4 more
wiley +1 more source
Introduction Smoking poses a serious threat to cardiovascular health. The aim of the study is to evaluate the global, regional, and national burden of smokingattributable cardiovascular disease (CVD) and set priorities for future tobacco control ...
Wei Shi +8 more
core +1 more source