Results 121 to 130 of about 1,296,781 (299)

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Current trends and projections for potential acupuncture needs globally and in China: evidence from the Global Burden of Disease Study 2021

Chinese Medicine
Background Acupuncture plays a vital role in managing musculoskeletal, neurological, gastrointestinal, and cancer-related conditions and significantly improves individual quality of life and societal well-being. However, despite its demonstrated benefits,
Zihan Yin, Ziwen Chen, Fanrong Liang, Ling Zhao   +3 more
doaj   +1 more source

Economic benefit of tuberculosis control [PDF]

Tuberculosis is the most important infectious cause of adult deaths after HIV/AIDS in low- and middle-income countries. This paper evaluates the economic benefits of extending the World Health Organization's DOTS Strategy (a multi-component approach that
Adeyi, Olusoji, Darley, Sarah, Dye, Christopher, Floyd, Katherine, Klein, Eili, Laxminarayan, Ramanan   +5 more
core  

Global burden of cardiovascular disease [PDF]

Nature Reviews Cardiology, 2013
openaire   +2 more sources

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

Molecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh, Nitzan Medina‐Itzhaki, Milena Chekov, Eden Gal‐Swisa, Roba Gabesh‐Wahabi, Inbar Savyon, Inna Naroditsky, Hilary A. Kenny, Basem Fares, Lina Korsensky, Einav Girsh, Liron Berger, Ruth Perets   +12 more
wiley   +1 more source

Global burden of metabolic diseases, 1990–2021

Metabolism
Common metabolic diseases, such as type 2 diabetes mellitus (T2DM), hypertension, obesity, hypercholesterolemia, and metabolic dysfunction-associated steatotic liver disease (MASLD), have become a global health burden in the last three decades. The Global Burden of Disease, Injuries, and Risk Factors Study (GBD) data enables the first insights into the
Zhang, Huai, Zhou, Xiao-Dong, Shapiro, Michael D, Lip, Gregory Y H, Tilg, Herbert, Valenti, Luca, Somers, Virend K, Byrne, Christopher D, Targher, Giovanni, Yang, Wah, Viveiros, Octavio, Opio, Christopher Kenneth, Mantzoros, Christos S, Ryan, John D, Kok, Kenneth Yuh Yen, Jumaev, Nozim Adxamovich, Perera, Nilanka, Robertson, Andrew Gerard, Abu-Abeid, Adam, Misra, Anoop, Wong, Yu Jun, Ruiz-Úcar, Elena, Ospanov, Oral, Kızılkaya, Mehmet Celal, Luo, Fei, Méndez-Sánchez, Nahum, Zuluaga, Mauricio, Lonardo, Amedeo, Al Momani, Hazem, Toro-Huamanchumo, Carlos Jesus, Adams, Leon, Al-Busafi, Said A, Sharara, Ala I, Chan, Wah-Kheong, Abbas, Syed Imran, Sookoian, Silvia, Treeprasertsuk, Sombat, Ocama, Ponsiano, Alswat, Khalid, Kong, Alice Pik-Shan, Ataya, Karim, Lim-Loo, Michelle Ching, Oviedo, Rodolfo J, Szepietowski, Olivia, Fouad, Yasser, Zhang, Huijie, Abdelbaki, Tamer N, Katsouras, Christos S, Prasad, Arun, Thaher, Omar, Ali, Arshad, Molina, Gabriel Alejandro, Sung, Ki-Chul, Chen, Qin-Fen, Lesmana, Cosmas Rinaldi Adithya, Zheng, Ming-Hua   +55 more
openaire   +5 more sources

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Revisiting Mission‐Oriented Cancer Research to tackle the increasing burden of cancer in Europe–a policy perspective

Molecular Oncology, EarlyView.
Translational cancer research and its implementation through competitively selected Comprehensive Cancer Centers across Europe should be the primary policy focus for addressing the increasing cancer burden in Europe and counteract the present main strategy to convert cancer to a chronic disease.
Manuel Heitor, Julio Celis, Ulrik Ringborg   +2 more
wiley   +1 more source