Results 101 to 110 of about 169,062,891 (293)

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

The global Asthma report 2014 [PDF]

, 2014
Provides up-to-date information about asthma, and summarises what is known and where the gaps lie. The report also makes recommendations to authorities on required actions.

core  

Trends and burden of tobacco use in Nepal: Insights from the Global Burden of Disease study 1990–2021

Tobacco Prevention and Cessation
Introduction Tobacco consumption is a significant public health problem in Nepal, accounting for 39200 deaths each year, accounting for 23.7% of all deaths.
Kiran Paudel, Kamal Gautam, Sandhya Niroula, Sandesh Bhusal, Jeffrey A. Wickersham, Md. Safaet Hossain Sujan, Bhakta KC, Tara B. Adhikari, Roman Shrestha   +8 more
doaj   +1 more source

Global Burden of Cardiovascular Disease

Cardiovascular Innovations and Applications, 2016
Cardiovascular disease (CVD) is the number one cause of mortality world-wide and places a high medical and socioeconomic burden on developing countries. Our understanding of CVD and its evolution over the last 100 years has altered considerably.
Christopher Estel, C. Richard Conti
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

, 2018
BACKGROUND: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions.
Global Burden of Disease, Collaboration, Petzold, Max,   +1 more
core   +1 more source

Global losses due to dairy cattle diseases: A comorbidity-adjusted economic analysis

Journal of Dairy Science
: An economic simulation was carried out over 183 milk-producing countries to estimate the global economic impacts of 12 dairy cattle diseases and health conditions: mastitis (subclinical and clinical), lameness, paratuberculosis (Johne's disease ...
Philip Rasmussen, Herman W. Barkema, Prince P. Osei, James Taylor, Alexandra P. Shaw, Beate Conrady, Gemma Chaters, Violeta Muñoz, David C. Hall, Ofosuhene O. Apenteng, Jonathan Rushton, Paul R. Torgerson   +11 more
doaj   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Pain and the global burden of disease [PDF]

Pain, 2016
Rice, Andrew S. C., Smith, Blair H., Blyth, Fiona M.   +2 more
openaire   +3 more sources