Results 81 to 90 of about 630,314 (297)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016

, 2018
BACKGROUND: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions.
Global Burden of Disease, Collaboration, Petzold, Max,   +1 more
core   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

The global burden of disease study 2010 : interpretation and implications for the neglected tropical diseases [PDF]

, 2014
18/02/15 meb.
Furst, T, Bolliger, Ian, Hotez, Peter J., Furst, T., Johns, Nicole E., Wilma A Stolk, Naghavi, Mohsen, Pion, Sébastien, Lozano, Rafael, Undurraga, E. A., Donald S. Shepard (7252025), Johns, N. E., Stolk, Wilma, Donald S Shepard, Sébastien D S Pion, Utzinger, J, Rashmi Jasrasaria, Coffeng, Luc, F��vre, Eric M., Murdoch, M. E., Utzinger, J., Boussinesq, M., Murray, C.J.L., Murray, Christopher JL, Undurraga, E.A., Halasa, Y. A., Halasa, Yara A, Brooker, SJ, Shepard, Donald S., Lozano, R, King, C. H., Peter J. Hotez (7388189), Boussinesq, Michel, Hotez, PJ, Undurraga, Eduardo A, Utzinger, J��rg, Sébastien D. S. Pion (9017108), Brown, AS, Hélène Carabin (62192), Simon J. Brooker (7181366), Michele E. Murdoch (10960929), Wang, M, Pullan, Rachel L., Murray, Christopher J.L., Ramaiah, K. D., Pion, Sébastien DS, Coffeng, L.E., Stolk, Wilma; id_orcid, Yara A. Halasa (16673166), Murdoch, Michele E, Christine M Budke, Hotez, Peter J, Thomas Fürst (128978), Budke, Christine M., Bolliger, I., Alvarado, Miriam, Stolk, Wilma A., Fèvre, Eric M., Miriam Alvarado (603840), de Silva, Nilanthi, Buckle, G., Rafael Lozano (234333), Stolk, WA, King, Charles H., Mohsen Naghavi, Kapa D Ramaiah, Wang, MR, Peter J Hotez, Alvarado, M., Smith, J.L., María-Gloria Basáñez (40535), Michele E Murdoch, Jürg Utzinger (39609), Hélène Carabin, Naghavi, M., Brooker, S. J., Fèvre, Eric M, Johns, N.E., Geoffrey Buckle (603843), Wang, M., Hotez, P. J., O'Hanlon, S., Buckle, G, Rachel L. Pullan (7181375), F��rst, Thomas, Murdoch, ME, Halasa, Y.A., Smith, Jennifer L, Ami Shah Brown, Johns, NE, Nilanthi de Silva (250339), Thomas Roberts, Pion, Sébastien D. S., Wang, Mengru, Rashmi Jasrasaria (603844), King, Charles H, Christopher J. L. Murray (8067506), Ramaiah, Kapa D, Ramaiah, KD, Buckle, Geoffrey, Basanez, M. G., Budke, Christine M, Rafael Lozano, Fevre, EM, Basáñez, María-Gloria, Halasa, YA, Roberts, Thomas, Simon J Brooker, Keiser, J., Bourne, Rupert, O'Hanlon, S, Carabin, H��l��ne, Murdoch, Michele E., Murray, Christopher J. L., O'Hanlon, Simon, Kapa D. Ramaiah (11707974), Jennifer L Smith, Carabin, H., Bourne, R, Stolk, Wilma A, Thomas Roberts (603847), Murdoch, M.E., Simon O'Hanlon, Fürst, Thomas, Pullan, RL, Mengru Wang (603848), Coffeng, LE, Miriam Alvarado, María-Gloria Basáñez, Nicole E Johns, Ramaiah, Kapa D., Smith, JL, Coffeng, Luc; id_orcid, Pion, S��bastien D. S., Mohsen Naghavi (34491), Shepard, DS, Halasa, Yara A., Smith, Jennifer L., Michel Boussinesq (81042), Eduardo A Undurraga, Rachel L Pullan, Basanez, MG, Wilma A. Stolk (7181429), Smith, J. L., Charles H King, Eric M. Fèvre (6859703), Nicole E. Johns (7304045), O’Hanlon, Simon, Boussinesq, M, Pion, S.D.S., Roberts, T., Christopher J L Murray, Jürg Utzinger, Basanez, M-G, Fevre, E. M., Naghavi, M, Shepard, D. S., Jasrasaria, R, Shepard, Donald S, Undurraga, EA, Rupert Bourne, Pullan, R. L., Stolk, W. A., Bourne, R., Jasrasaria, Rashmi, Keiser, Jennifer, Coffeng, Luc E, Pion, Sébastien D.S., Eduardo A. Undurraga (10024643), Brown, Ami Shah, Bolliger, I, Budke, CM, Brooker, Simon J., Alvarado, M, Jennifer Keiser, Carabin, H, Fuerst, T, Utzinger, Jürg, Brown, A. S., Budke, C.M., Ramaiah, K.D., Michel Boussinesq, Ami S. Brown (16673163), Carabin, Hélène, Mengru Wang, Stolk, W.A., Murray, C. J. L., Jennifer Keiser (39606), Ian Bolliger, Keizer, Johannes, Jasrasaria, R., Wang, M. R., King, C.H., Lozano, R., Ian Bolliger (603841), Pion, SDS, Luc E Coffeng, Keiser, J, Coffeng, Luc E., Bas����ez, Mar��a-Gloria, Brooker, S.J., Rupert R. A. Bourne (3232398), Geoffrey Buckle, Luc E. Coffeng (8964884), King, CH, Budke, C. M., Shepard, D.S., Johns, Nicole E, Simon O'Hanlon (401898), Murray, CJL, Pullan, Rachel L, Pullan, R.L., Brooker, Simon J, Eric M Fèvre, Jennifer L. Smith (7339208), Coffeng, L. E., Basanez, M.-G., Undurraga, Eduardo A., Yara A Halasa, Brown, A.S., Roberts, T, Thomas Fürst, Charles H. King (7372412), Christine M. Budke (10752688)   +223 more
core   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990-2013: a systematic analysis for the Global Burden of Disease Study 2013.

, 2015
BACKGROUND: Up-to-date evidence about levels and trends in disease and injury incidence, prevalence, and years lived with disability (YLDs) is an essential input into global, regional, and national health policies.
Global Burden of Disease Study 2013 Collaborators
core   +1 more source

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016

Tropical Medicine and Health, 2018
Background According to the World Health Organization, Nigeria is one of the countries with a high burden of tuberculosis (TB) worldwide. Improving the burden of TB among HIV-negative people would require comprehensive and up-to-date data to inform ...
Felix Akpojene Ogbo, Pascal Ogeleka, Anselm Okoro, Bolajoko O. Olusanya, Jacob Olusanya, Ifegwu K. Ifegwu, Akorede O. Awosemo, John Eastwood, Andrew Page   +8 more
doaj   +1 more source

The burden of mental disorders in the Eastern Mediterranean region, 1990–2015: findings from the global burden of disease 2015 study

, 2017
Objectives Mental disorders are among the leading causes of nonfatal burden of disease globally. Methods We used the global burden of diseases, injuries, and risk factors study 2015 to examine the burden of mental disorders in the Eastern Mediterranean ...
Global Burden of Disease 2015 Eastern Mediterranean Region Mental Health Collaborators
core   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source