Results 91 to 100 of about 169,062,891 (293)

Global, Regional, and National Burden of Nontraumatic Subarachnoid Hemorrhage: The Global Burden of Disease Study 2021 [PDF]

Importance: Nontraumatic subarachnoid hemorrhage (SAH) represents the third most common stroke type with unique etiologies, risk factors, diagnostics, and treatments. Nevertheless, epidemiological studies often cluster SAH with other stroke types leaving
GBD 2021 Global Subarachnoid Hemorrhage Risk Factors Collaborators
core   +1 more source

The burden of disease in Greece, health loss, risk factors, and health financing, 2000-16: an analysis of the Global Burden of Disease Study 2016. [PDF]

, 2018
BACKGROUND: Following the economic crisis in Greece in 2010, the country's ongoing austerity measures include a substantial contraction of health-care expenditure, with reports of subsequent negative health consequences.
Global Burden of Disease 2016 Greece Collaborators
core   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Directing diarrhoeal disease research towards disease-burden reduction [PDF]

, 2009
Despite gains in controlling mortality relating to diarrhoeal disease, the burden of disease remains unacceptably high. To refocus health research to target disease-burden reduction as the goal of research in child health, the Child Health and Nutrition ...
Bhutta, Zulfiqar Ahmed, Rudan, Igor, Snyder, John D., Lanata, Claudio F., Lanata, Claudio F, Black, Robert E, Mahalanabis, Dilip, Bhutta, Zulfiqar A, Bhatnagar, Shinjini, Bhutta, Zulfiqar A., Walker, Damian G, Salam, Mohammed Abdus, Snyder, John D, Fontaine, Olivier, Kosek, Margaret, Black, Robert E., Walker, Damian G.   +16 more
core  

Tuberculosis disease burden and attributable risk factors in Nigeria, 1990–2016

Tropical Medicine and Health, 2018
Background According to the World Health Organization, Nigeria is one of the countries with a high burden of tuberculosis (TB) worldwide. Improving the burden of TB among HIV-negative people would require comprehensive and up-to-date data to inform ...
Felix Akpojene Ogbo, Pascal Ogeleka, Anselm Okoro, Bolajoko O. Olusanya, Jacob Olusanya, Ifegwu K. Ifegwu, Akorede O. Awosemo, John Eastwood, Andrew Page   +8 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Degradation mechanism of the von Willebrand factor A2 domain by nattokinase

FEBS Letters, EarlyView.
Nattokinase, a natto‐derived protease, exhibits potent antithrombotic effects. This study demonstrates that nattokinase directly cleaves the von Willebrand factor (vWF) A2 domain in vitro. Unlike the native regulator ADAMTS13, nattokinase degrades folded vWF independently of shear stress.
Ryuichi Hyakumoto, Masatomo So, Ayako Furukawa, Kenji Sugase   +3 more
wiley   +1 more source

The burden of primary liver cancer and underlying etiologies from 1990 to 2015 at the global, regional, and national level: Results from the Global Burden of Disease Study 2015 [PDF]

, 2017
Importance Liver cancer is among the leading causes of cancer deaths globally. The most common causes for liver cancer include hepatitis B virus (HBV) and hepatitis C virus (HCV) infection and alcohol use.
Hay, Simon, Collaboration,, Global Burden of Disease Liver Cancer   +1 more
core   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Factors leading to excessive fatigue in nurses – a three-year follow-up study

BMC Nursing
Background Global nursing shortages necessitate the identification of mitigatable factors that may reduce nursing absence and turnover. Fatigue has been shown to be associated with these issues. This study aimed to identify factors leading to development
Stand Hiestand, Siri Waage, Ingeborg Forthun, Ståle Pallesen, Bjørn Bjorvatn   +4 more
doaj   +1 more source