Results 201 to 210 of about 11,636,692 (262)

Global Change Reshapes Northern Lakes Towards Browner, More Nutrient-Depleted and Nitrogen-Limited Conditions With Contrasting Impacts on Phytoplankton Biomass. [PDF]

Glob Chang Biol
Bergström AK, Paltsev A, Hessen DO, Kortelainen P, Vuorenmaa J, de Wit HA, Lau DCP, Vrede T, Vuorio K, Isles PDF, Jonsson A, Geibrink E, Kahilainen KK, Drakare S, Creed IF.   +14 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Global Change Asymmetrically Rewires Ecosystems. [PDF]

Ecol Lett
Ward CA, Tunney TD, Donohue I, Bieg C, Hale KRS, McMeans BC, Moore JC, McCann KS.   +7 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Global change factors differ in effect when acting alone and in a multi-factor background. [PDF]

Nat Commun
Rongstock R, Li H, Lehmann A, Wulf A, Rillig MC.   +4 more
europepmc   +1 more source

Bridging the gap: a genetically validated avian chorioallantoic membrane platform for investigation of spontaneous circulating tumor cells

Molecular Oncology, EarlyView.
We established the avian chorioallantoic membrane (CAM) assay as a scalable in vivo model for studying circulating tumor cells (CTCs). Human gastrointestinal tumors spontaneously released genetically validated CTCs that were detected across multiple platforms, demonstrating that the CAM model provides an accessible tool for investigating early cancer ...
Dennis Roth, Rui P. L. Neves, Julia Geheb, Christian Ballmeyer, Nathalie Gaßmann, Kiki C. Andree, Monica Sudarsanam, Christiane Driemel, Celine Örencik, Andrè Franken, Eslam Elmaghraby, Sven H. Loosen, Roderburg Christoph, Sebastian Schoelch, Hans Neubauer, Wolfram T. Knoefel, Nikolas H. Stoecklein, Georg Fluegen   +17 more
wiley   +1 more source

Tree diversity is changing across tropical Andean and Amazonian forests in response to global change. [PDF]

Nat Ecol Evol
Fadrique B, Costa F, Cuesta F, Arellano G, Cayuela L, Baker TR, Draper FC, Esquivel-Muelbert A, Ter Steege H, Bauters M, Aguirre-Gutiérrez J, Aguirre-Mendoza Z, Alexiades MN, Alvarez-Davila E, Arets E, Ayala E, Aymard CGA, Baccaro F, Báez S, Baraloto C, Barbosa RI, Barbosa Camargo P, Barlow J, Barni PE, Barroso J, Benchimol M, Bennett AC, Berenguer E, Blanc L, Bonal D, Bongers F, Brienen R, Brown F, Bt Andrade M, Burban B, Burnham RJ, Camargo JL, Carvalho SPC, Castilho C, Chave J, Coelho de Souza F, Comiskey J, da Costa L, de Lima RB, de Oliveira EA, de Oliveira RLC, de Oliveira Perdiz R, De Rutte J, Del Aguila-Pasquel J, Derroire G, Di Fiore A, Disney M, Duque A, Emilio T, Farfan-Rios W, Fauset S, Fearnside PM, Feeley KJ, Feldpausch TR, Ferreira J, Ferreira L, Flores Llampazo GR, Galbraith D, García-Cabrera K, García Criado M, Gloor E, Grandez-Rios JM, Hérault B, Homeier J, Honorio Coronado EN, Huamantupa-Chuquimaco I, Huaraca Huasco W, Huillca-Aedo YT, Idárraga Á, Jadán-Maza O, Kalamandeen M, Killeen TJ, Laurance SGW, Laurance WF, Levesley A, Lopez W, Macía MJ, Magnusson WE, Malhi Y, Manzatto AG, Marimon BS, Marimon Junior BH, Martínez-Villa JA, Medeiros MB, Melgaço K, Melo L, Metzker T, Monteagudo A, Morandi PS, Myers JA, Nascimento HM, Nascimento R, Neill D, Nieto-Ariza B, Palacios WA, Palacios-Ramos S, Pallqui-Camacho NC, Pardo Molina G, Peacock J, Peña MA, Pennington RT, Peñuela MC, Peres CA, Pérez ÁJ, Pickavance GC, Pinto E, Pipoly J, Pitman N, Prieto A, Ramírez-Angulo H, Reis SM, Restrepo Z, Reynel C, Ribeiro S, Rivas-Torres G, Rojas R, Rudas A, Salinas N, Salomão RP, Santana F, Schietti J, Schwartz G, Serrano J, Silman M, Silva C, Silva CA, Silva RC, Silva RSA, Silva-Espejo J, Silveira M, Simon MF, Soto-Shareva YC, Souza PF, Storck-Tonon D, Stropp J, Swamy V, Tello JS, Terborgh J, Thomas R, Torres-Lezama A, Vale JD, Valenzuela Gamarra L, van der Heijden G, van der Hout P, van der Meer PJ, Vasquez Martinez R, Vedovato L, Verbeeck H, Vieira I, Vieira SA, Vilanova E, Vinceti B, Vos VA, Zagt R, Zuidema PA, Phillips OL.   +160 more
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Identifying and addressing the anthropogenic drivers of global change in the North Sea: a systematic map. [PDF]

Environ Evid
Blöcker AM, Auch D, Gutte HM, Biederbick J, Asselot R, Färber L, Börner G, Kamberi E, Madiraca F, Ofelio C, Steidle L, Moullec F.   +11 more
europepmc   +1 more source

Polarization‐resolved femtosecond Vis/IR spectroscopy tailored for resolving weak signals in biological samples using minimal sample volume

FEBS Open Bio, EarlyView.
Unique biological samples, such as site‐specific mutant proteins, are available only in limited quantities. Here, we present a polarization‐resolved transient infrared spectroscopy setup with referencing to improve signal‐to‐noise tailored towards tracing small signals. We provide an overview of characterizing the excitation conditions for polarization‐
Clark Zahn, Karsten Heyne
wiley   +1 more source