Results 181 to 190 of about 11,636,692 (262)

Meta-analysis reveals asymmetric root and microbial phenology shifts under global change. [PDF]

Nat Commun
Zhao C, Qian Z, Liang S, Wang S, Luke McCormack M, Chen W.   +5 more
europepmc   +1 more source

Partial FAK suppression promotes tumor growth, an effect reversed by macrophage p110δ PI3K inactivation

Molecular Oncology, EarlyView.
Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou, Niki Tzenaki, Anna Tsapara, Maria Tzardi, Evangelia A. Papakonstanti   +4 more
wiley   +1 more source

Biological traits predict species' time-varying responses to multiple global change drivers. [PDF]

Nat Commun
Sasaki T, Iwachido Y, Lam-Gordillo O, Cook KM, Douglas EJ, Gladstone-Gallagher RV, Greenfield B, Hailes S, Carter K, Ishii NI, Takayama Y, Shimode S, Kagami M, Hewitt JE, Thrush SF, Lohrer AM.   +15 more
europepmc   +1 more source

Articulating the JACC Journals' Direction in Times of Global Change. [PDF]

JACC Asia
Krumholz HM, Bozkurt B, Chandrashekhar Y, Ky B, Mann DL, Moliterno DJ, Shivkumar K, Silversides CK, Tang GHL, Wang J.   +9 more
europepmc   +5 more sources

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Congo Basin Carbon Cycle Responses to Global Change. [PDF]

Glob Chang Biol
Worden S, Fu R, Bloom AA, Bauters M, Verbeeck H, Fatoyinbo T, Hubau W, Koutika LS, Kengdo SK, Maes SL, Medjibe V, Russo NJ, Saatchi S, Sagang LB, Smith TB, Sonwa DJ, Boeckx P, Ordway EM.   +17 more
europepmc   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Contrasting vulnerability profiles for insular assemblages of birds and mammals facing global change. [PDF]

Conserv Biol
Marino C, Benítez-López A, Butt N, Caetano G, Capdevila P, Denelle P, Etard A, Fernández Palacios JM, Ferreiro-Arias I, Leclerc C, Lenoir J, Philippe-Lesaffre M, Rigal F, Bellard C.   +13 more
europepmc   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source

Advancing the science of systemic environmental risk in an era of global change. [PDF]

Fundam Res
Wang G, Cao S, Wu J.
europepmc   +1 more source