Results 171 to 180 of about 11,636,692 (262)

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Integrating HIV services in an era of global change. [PDF]

J Int AIDS Soc
Ratevosian J, Bekker LG, Eakle R, Baral S, Cepeda J, Dugas L, Dybul M, Alleyne G, Eholie SP, Esom K, Grimsrud A, Havlir D, Kamarulzaman A, Kasaie P, Kazatchkine M, Kilonzo N, Klag M, Klein M, Lewin S, Luo C, Makofane K, Martin N, Mayer K, Millett G, Ntusi N, Pace L, Piot P, Poniatowski B, Daskalakis D, Pozniak A, Quinn T, Reynolds C, Rockstroh J, Sippel S, Spire B, Starrs A, Strathdee S, Schechter M, Thomson N, Vickerman P, Weir B, Beyrer C.   +41 more
europepmc   +1 more source

The U.S. Global Change Research Program

This is the homepage of the U.S. Global Research Program (USGCRP), an initiative to support research on the interactions of natural and human-induced changes in the global environment and their implications for society.

core  

CEACAM1 participation in breast cancer progression

Molecular Oncology, EarlyView.
In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin, Irina Kube‐Golovin, Anatolii Romaniuk, Gunther Wennemuth   +3 more
wiley   +1 more source

Resurrection ecology: An approach for understanding eco-evolutionary plant-microbe interactions under global change. [PDF]

Am J Bot
Lumibao CY.
europepmc   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Vulnerability of Pampean Coastal Lizards to Global Change: Divergent Responses of Endemic Specialists and Widespread Generalists. [PDF]

Biology (Basel)
Dajil JE, Block C, Vega LE, Garzo PA, Stellatelli OA.   +4 more
europepmc   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

Molecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho, Chenqian Liu, W. Lee Kraus   +2 more
wiley   +1 more source

Top-Down and Bottom-Up Effects on Insect Herbivores Under Global Change-A Meta-Analysis. [PDF]

Ecol Lett
Vidal MC, Comerford MS, Maguire B, Murphy SM.   +3 more
europepmc   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source