Results 161 to 170 of about 12,171,189 (307)

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Extending Trait-Based Ecology Across Disciplines in the Face of Global Change. [PDF]

Ecol Evol
Gonçalves-Souza T, Au TF, Brinkhoff RE, McPherson MR, Raubenheimer SL, Rocci KS, Song Y, Zheng L, Head JR, Chen X, Bardou R, Reich PB.   +11 more
europepmc   +1 more source

The U.S. Global Change Research Program

This is the homepage of the U.S. Global Research Program (USGCRP), an initiative to support research on the interactions of natural and human-induced changes in the global environment and their implications for society.

core  

A Supplement to the President's Budget for Fiscal Year 2010

, 2010
Annual report of the U.S. Global Change Research Program documenting activities and research, goals for the upcoming year, proposed budget considerations, and other information about the organization for fiscal year ...
U.S. Global Change Research Program (2009-2010)
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Global Change Reshapes Biosynthesis of LC-PUFA in Northern Lake Food Webs. [PDF]

Glob Chang Biol
Pilecky M, Vuorio K, Rigaud C, Calderini M, Kahilainen KK, Ruokonen TJ, Kainz MJ, Vesterinen J, Taipale SJ.   +8 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Sector-specific clean water scarcity and competition under global change. [PDF]

NPJ Clean Water
Cárdenas Belleza GA, van Beek LPHR, Bierkens MFP, Jones ER, van Vliet MTH.   +4 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Global Change Impacts on Mineral-Associated Organic Matter: Consequences for Soil Carbon Persistence. [PDF]

Glob Chang Biol
Jia J, Feng X.
europepmc   +1 more source