Results 161 to 170 of about 11,636,692 (262)

Advancing mental health for all as a response to global change: WPA achievements under the Action Plan 2023-2026. [PDF]

World Psychiatry
Wasserman D, Arango C, Fiorillo A, Rao GP, Sanchez-Villanueva TS, Sylla A, Iosue M.   +6 more
europepmc   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Soil Biodiversity Supports Agroecosystem Services Under Multiple Global Change Factors. [PDF]

Glob Chang Biol
Garzón-Ladino C, Zhou G, Revillini D, Castejon S, Bao Y, Feng Y, Delgado-Baquerizo M.   +6 more
europepmc   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Plant-soil feedbacks benefit plant invaders under multiple global change factors. [PDF]

Natl Sci Rev
Cheng C, Liu Y, Wu J, van Kleunen M.
europepmc   +1 more source

Epigenetic silencing of the liver‐specific lncRNA LUNAR promotes liver cancer progression via NOTCH activation

Molecular Oncology, EarlyView.
LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang, Hyung Seok Kim, Geum Ok Baek, Moon Gyeong Yoon, Su In Lee, Jee‐Yeong Jeong, Ji Eun Han, Soon Sun Kim, Jae Youn Cheong, Jung Woo Eun   +9 more
wiley   +1 more source

From individuals to networks: The role of variation in plant-pollinator communities' responses to global change. [PDF]

J Anim Ecol
Crall JD, Gaiarsa MP.
europepmc   +1 more source

Single‐cell DNA methylation profiling: Technologies, computation, and applications in precision oncology

Molecular Oncology, EarlyView.
Single‐cell DNA methylation (scDNAme) profiling maps epimutational clonal evolution, revealing mechanisms of malignancy and therapeutic resistance across diverse cancer types. By providing a high‐resolution landscape of intratumoral heterogeneity, these technologies empower precise patient stratification, guide the development of enhanced ...
Ik Soo Kim
wiley   +1 more source

Publisher Correction: Impacts of long-term temperature change and variability on electricity investments

Nature Communications, 2022
Zarrar Khan, Gokul Iyer, Pralit Patel, Son Kim, Mohamad Hejazi, Casey Burleyson, Marshall Wise   +6 more
doaj   +1 more source

The Fragile Sink: Reconceptualizing Soil Carbon Stabilization and Its Vulnerability Under Global Change. [PDF]

Glob Chang Biol
Iqbal MM, Farooq MA, Lal R, Abdalla M, Smith P.   +4 more
europepmc   +1 more source