Results 71 to 80 of about 2,061,932 (305)

Towards typologies of urban climate and global environmental change

Environmental Research Letters, 2015
The beauty of cities is that every city is different. From the homogenizing perspective of global environmental change that speaks trouble. We need an understanding of which kind of cities can contribute what kind of measures to mitigate and adapt to ...
Felix Creutzig
doaj   +1 more source

Phenotypic and genotypic characterization of single circulating tumor cells in the follow‐up of high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Single circulating tumor cells (sCTCs) from high‐grade serous ovarian cancer patients were enriched, imaged, and genomically profiled using WGA and NGS at different time points during treatment. sCTCs revealed enrichment of alterations in Chromosomes 2, 7, and 12 as well as persistent or emerging oncogenic CNAs, supporting sCTC identity.
Carolin Salmon, Rui P. L. Neves, Nikolas H. Stoecklein, Sven‐Thorsten Liffers, Jens Siveke, Jan D. Kuhlmann, Pauline Wimberger, Paul Buderath, Rainer Kimmig, Sabine Kasimir‐Bauer   +9 more
wiley   +1 more source

The Promise and Problems of Pricing Carbon: Theory and Experience [PDF]

Because of the global commons nature of climate change, international cooperation among nations will likely be necessary for meaningful action at the global level.
Joseph E. Aldy, Robert N. Stavins
core   +6 more sources

Rationale and design of "Can Very Low Dose Rivaroxaban (VLDR) in addition to dual antiplatelet therapy improve thrombotic status in acute coronary syndrome (VaLiDate-R)" study : A randomised trial modulating endogenous fibrinolysis in patients with acute coronary syndrome [PDF]

, 2019
© The Author(s) 2019. This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the ...
Gorog, Diana A, Gue, Ying X, Kanji, Rahim, Srinivasan, Manivannan, Wellsted, David M, Wyatt, Solange   +5 more
core   +2 more sources

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Heroes and villains of world history across cultures [PDF]

, 2015
© 2015 Hanke et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are ...
A Appadurai, A Gupta, B Schwartz, C Calhoun, C Fowler, CG Sibley, CG Sibley, Chan-Hoong Leong, Chris G. Sibley, CN Macrae, César A Hidalgo, D Fuchs, D Rindskopf, Dario Paez, Denis J. Hilton, DJ Hilton, DJ Schneider, DO Sears, DO Sears, E Burke, E Hobsbawm, F Fukuyama, FJR Van de Vijver, G Hofstede, G Ritzer, Gail Moloney, Gisela Böhm, HK Bhabha, I Greenstein, Ilya Garber, J Henrich, J Olick, JA Hagenaars, James H. Liu, JH Liu, JH Liu, JH Liu, JH Liu, JH Liu, JV Wertsch, JX Inda, Katja Hanke, L van Ypersele, Laurent Licata, LK Muthén, M Bobowik, M Douglas, M Sahlins, MA Hogg, MA Leichtman, MC Nussbaum, MS Wilson, Olivier Klein, PD Bliese, R Inglehart, RD Kaplan, Rosa Cabecinhas, S Freud, S Moscovici, S Reicher, S Reicher, S van Hooft, Sammyh S. Khan, SE Asch, SH Schwartz, Stanley O. Gaines, Velichko Valchev, W Wagner, Wolfgang Wagner   +68 more
core   +5 more sources

Colorectal cancer‐derived FGF19 is a metabolically active serum biomarker that exerts enteroendocrine effects on mouse liver

Molecular Oncology, EarlyView.
Meta‐transcriptome analysis identified FGF19 as a peptide enteroendocrine hormone associated with colorectal cancer prognosis. In vivo xenograft models showed release of FGF19 into the blood at levels that correlated with tumor volumes. Tumoral‐FGF19 altered murine liver metabolism through FGFR4, thereby reducing bile acid synthesis and increasing ...
Jordan M. Beardsley, Michael W. Rohr, Joseph A. Goode, Sai Preethi Nakkina, Jignesh G. Parikh, Deborah A. Altomare   +5 more
wiley   +1 more source

A BARGAINING FRAMEWORK FOR THE GLOBAL COMMONS [PDF]

The global commons represents a class of environmental problems that require international cooperation. Global environmental problems arise because the actions of some individuals or governments in one location hold serious implications for individuals ...
Bromley, Daniel W.
core   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Negative emissions—Part 2: Costs, potentials and side effects

Environmental Research Letters, 2018
The most recent IPCC assessment has shown an important role for negative emissions technologies (NETs) in limiting global warming to 2 °C cost-effectively.
Sabine Fuss, William F Lamb, Max W Callaghan, Jérôme Hilaire, Felix Creutzig, Thorben Amann, Tim Beringer, Wagner de Oliveira Garcia, Jens Hartmann, Tarun Khanna, Gunnar Luderer, Gregory F Nemet, Joeri Rogelj, Pete Smith, José Luis Vicente Vicente, Jennifer Wilcox, Maria del Mar Zamora Dominguez, Jan C Minx   +17 more
doaj   +1 more source