Results 21 to 30 of about 5,281,369 (256)
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Poland’s Long‑Term Competitive Position from the Perspective of WEF Global Competitiveness Reports
Comparative Economic Research, 2018 Competitiveness is not clearly defined and there are different methods of measuring it. Analysis of the level of competitiveness on a macro scale is of interest to many entities. Competitiveness rankings are published in the Global Competitiveness Report
Stanisław Flejterski +1 more
doaj +1 more source
Epigenetic reprogramming of lineage switching in cancer
FEBS Letters, EarlyView.Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı +4 more
wiley +1 more source
IEEE AccessBased on self-determination theory, this study examined the mental and emotional states of final year Science and Engineering undergraduates in career change considerations.
Yit Sean Chong +2 more
doaj +1 more source
Prace Komisji Geografii Przemysłu Polskiego Towarzystwa Geograficznego, 2013 During recent decades, the rate of structural shifts in the world economy has been especially fast. One of the factors used to influence these processes was to actively develop hi-tech industries and information and communication technologies.
Irina A. Rodionova +1 more
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Transport, 2023 Logistics Performance (LP) is one of the fundamental catalysts that serve as a podium for the integration of the world economy. This study is conducted to observe the combined effects of Liner Shipping Connectivity (LSC) and Global Competitiveness Index
Yan-Chun Chen, Mohammad Kamrul Hasan
doaj +1 more source
Structural and biochemical analysis of a B12 superbinder
FEBS Letters, EarlyView.BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices +3 more
wiley +1 more source
Global Competitiveness and Innovation in the Period 2013-2015 [PDF]
Ovidius University Annals: Economic Sciences Series, 2016 Understanding the relationship between competitiveness and innovation has become a key topicin the literature in the past decades. In the twenty-first century innovation proves to be an enginefor competitiveness all over the world.
Sorin-George Toma +2 more
doaj
Metastatic niche shaped by host factors influences disseminated cancer cell fate
FEBS Letters, EarlyView.Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward +2 more
wiley +1 more source
Humanities & Social Sciences CommunicationsThis paper explores the mapping from specific digitalization practices to specific resilient performance against a great shock. Based on an adapted structure–conduct–performance framework, this paper hypothesizes by theoretically analyzing how the pre ...
Sirui Li +5 more
doaj +1 more source