Results 31 to 40 of about 5,281,369 (256)

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Analysis of Factors Affecting the Competitiveness of Indonesian Crude Palm Oil (CPO) Export in the Global Market

Indonesian Journal of Agricultural Research, 2020
This study aims to: (1) Analyze the development of Indonesian CPO export competitiveness in the global market from 1998 to 2017 (2) Analyze factors affecting the competitiveness of Indonesian CPO export in the global market from 1998 to 2017.
Mirawati Yanita, Dompak MT Napitupulu, Karina Rahmah   +2 more
doaj   +1 more source

Digitalization of Business as a Factor of Increasing its Competitiveness

Современная конкуренция, 2022
Digital transformation is the renewal of business processes using modern technologies to accelerate productivity and increase efficiency. The dynamics of the number of publications on this topic demonstrates an increase in interest in the problem, so ...
Pavel A. Afonin
doaj   +1 more source

The competitiveness of nations and implications for human development [PDF]

, 2011
This is the post-print version of the final paper published in Socio-Economic Planning Sciences. The published article is available from the link below. Changes resulting from the publishing process, such as peer review, editing, corrections, structural ...
Özgür Kabak, Ülengin, F, Kabak, Özgür, Parker, Barnett R., Emel Aktas, Parker, BR, Barnett R. Parker, Aktas, E, Önsel Ekici, Şule, Aktaş, Emel, Ülengin, Füsun, Önsel, S, Kabak, Ö, Sule Önsel, Füsun Ülengin   +14 more
core   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

THE STATE OF THE WORLD ECONOMY AS A THREAT TO RUSSIA’S SECURITY: PUBLIC ESTIMATES AND INFLUENCING FACTORS

Стратегические решения и риск-менеджмент, 2019
This article is aimed at determining the significance of the state of the world economy as a threat to national security for the public of the Russia, as well as the formalization of the factors determining this.
V. V. Karginova-Gubinova
doaj   +1 more source

Global Economic Relations of a Region in the Investigations of the Institute of Economics of the Ural Branch of the Russian Academy of Sciences [PDF]

Экономика региона, 2018
In current geo-economic conditions, we need to consider the foreign economic factor as an instrument for structural changes, for the diversification of regional economy, as well as for the realization of a policy of import substitution, including ...
Elena Leonidovna Andreeva, Andrey Aleksandrovich Maltsev, Mikhail Ivanovich Maslennikov, Artem Vitalyevich Ratner   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

Molecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim, Maryam Aslam, Elouise Torruella, Alphons Sony, Asif Rahman, Simira Smith, Columba de la Parra, Moira Sauane   +7 more
wiley   +1 more source