Results 31 to 40 of about 8,665,882 (252)

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Targeting transcription factors associated with hemoglobinopathies: Lessons from successful interventions and implications for cancer

Molecular Oncology, EarlyView.
This review summarizes the transcription factors, repressive chromatin‐modifying complexes, and epigenetic mechanisms that control fetal hemoglobin repression. Notably, many regulators of γ‐globin silencing also function in transcriptional and epigenetic networks that drive cancer, highlighting opportunities to translate advances in hemoglobinopathy ...
Meigen Yu, Puspa Das, Xing Zhang, Xiaodong Cheng   +3 more
wiley   +1 more source

Competitiveness of innovation-driven economies: Insights from selected European countries [PDF]

International Entrepreneurship Review, 2019
Objective: The aim of this paper is to analyse the role of innovation in competitiveness development and to identify the most competitive European economies.
Maria Urbaniec
doaj   +3 more sources

Knowledge economy readiness, innovativeness and competitiveness of the Western Balkan countries [PDF]

Industrija, 2015
The Western Balkan countries have set themselves the goal to join the European Union as soon as possible. Accordingly, they must adjust the key components of their development policies to the Europe 2020 strategy, focusing on key priorities such as smart,
Cvetanović Slobodan, Ilić Vojislav, Despotović Danijela, Nedić Vladimir   +3 more
doaj   +1 more source

Unraveling the epigenetic code in cancer cell–tumor microenvironment crosstalk

Molecular Oncology, EarlyView.
Epigenetic regulation is a key driver of cancer development and progression. Diverse epigenetic alterations in cancer cells and components of the tumor microenvironment (TME) orchestrate their communication through multiple mechanisms. We discuss how the epigenetic code coordinates bidirectional cancer cell–TME crosstalk to promote cancer progression ...
Ji Hoon Park, Mi‐Young Kim
wiley   +1 more source

Competitiveness and Labour Productivity in Context of Composite Indicators [PDF]

Statistika: Statistics and Economy Journal, 2013
The productivity measurement constitutes an important part of economic analysis. It is always connected to a competitiveness analysis of a country.
Lenka Hudrlíková, Kristýna Vltavská
doaj  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

An innovative perspective on the impact of innovation on global competitiveness: comparative analysis of EU13 and EU15 countries [PDF]

, 2023
This study examines the relationship between innovation and global competitiveness in European Union (EU28) member states and the differences between EU13 and EU15 countries categorised by wealth level from 1997 to 2019.
Çetin, Melike, Erkişi, Kemal
core   +1 more source

ECONOMIC RESILIENCE AND COMPETITIVENESS: A COMPARATIVE ANALYSIS OF THE VISEGRAD GROUP COUNTRIES

Фінансово-кредитна діяльність: проблеми теорії та практики
The article examines the relationship between resilience and competitiveness of national economies in the Visegrad Group countries through a comparative analysis of the World Competitiveness Index and the Global Resilience Index. All four countries show
Юрій Уманців, Діана Шкуропадська, Катерина Ніколаєць, Юлія Ясько, Вікторія Хрустальова, Таміла Щербакова   +5 more
doaj   +1 more source