Results 51 to 60 of about 15,173 (297)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Oscillating global continua of positive solutions of second order Neumann problem with a set-valued term [PDF]

open access: yesBoundary Value Problems, 2012
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +1 more source

Structure and dimension of global branches of solutions to multiparameter nonlinear equations [PDF]

open access: yes, 1985
A general study of the dimension and connectivity properties of branches of solutions of equations depending on n-parameters are studied using the homotopy properties of 0-epi ...
Pejsachowicz, Jacobo   +6 more
core  

El kaizen en una organización deportiva: un esquema de mejora continua

open access: yesAdministración & Desarrollo, 2012
La industria del fútbol ha experimentado en los últimos años un extraordinario crecimiento que se ha representado entre el 10 y el 15% dependiendo de su mercado por algunos autores.
Manuel Francisco Suarez Barraza   +1 more
doaj   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Decomposable and Indecomposable Continua

open access: yes
There follows self-contained proofs of the existence of indecomposable continua and hereditarily indecomposable continua in the plane, and of Knaster’s theorem of existence and Mazurkiewicz’s theorem on the Baire category of the set of hereditarily ...
Buffoni, Boris, Toland, John
core   +1 more source

Existence, multiplicity, and bifurcation in systems of ordinary differential equations

open access: yesElectronic Journal of Differential Equations, 2007
We prove new non-resonance conditions for boundary value problems for two dimensional systems of ordinary differential equations. We apply these results to the existence of solutions to nonlinear problems.
James R. Ward Jr.
doaj  

Conhecimentos e práticas dos enfermeiros na administração de terapêutica antineoplásica sistémica: um estudo transversal

open access: yesOnco.News
Introdução: A administração de terapêutica antineoplásica sistémica (TANP) exige dos enfermeiros conhecimentos e competências específicas que garantam uma prática segura e de qualidade.
Celina Ferreira Amaral   +1 more
doaj   +1 more source

Detección de necesidades de formación del profesorado de los institutos tecnológicos de Quintana Roo, México, basadas en competencias profesionales

open access: yesEducar, 2015
Este artículo señala una investigación evaluativa de las competencias docentes del profesorado de los institutos tecnológicos (IT) de Quintana Roo, México.
María Magdalena Ku Mota   +1 more
doaj   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

open access: yesFEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

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