From Adult to Adolescent: Alignment in Clinical Trials and Outcomes in Axial Spondyloarthritis
Spondyloarthritis (SpA) is a group of chronic inflammatory diseases encompassing axial and peripheral forms, with up to 20% of patients developing symptoms before age 16. Despite this substantial pediatric burden, treatment options for juvenile‐onset SpA (JSpA), particularly those with axial disease (axJSpA), remain limited.
Pamela F. Weiss +9 more
wiley +1 more source
Objective To assess the validity of the Patient‐Reported Outcomes Measurement Information System (PROMIS) Pediatric measures in patients with chronic nonbacterial osteomyelitis (CNO). Methods Within the longitudinal patient registry of CNO, English‐speaking patients aged 8 years and older self‐reported PROMIS Pediatric measures of fatigue, pain ...
Mary M. Eckert +43 more
wiley +1 more source
Objective The objective of this scoping review was to synthesize evidence on the proportion of individuals living with Sjögren's disease who experience central nervous system (CNS) manifestations. Methods We searched MEDLINE (via PubMed) and Embase from 1980 through January 29, 2026, and the ECRI Guidelines Trust from 2020 through January 29, 2026 ...
Arun Varadhachary +21 more
wiley +1 more source
Gradient Descent with Random Initialization: Fast Global Convergence for Nonconvex Phase Retrieval. [PDF]
Chen Y, Chi Y, Fan J, Ma C.
europepmc +1 more source
Patients improve, patterns persist: longitudinal stability of RA joint involvement patterns
Objective Rheumatoid arthritis is a heterogeneous disease. Data‐driven approaches, from synovial histology to joint involvement patterns (JIPs), have sought to define clinically meaningful subgroups. Whether these subgroups represent stable phenotypes or transient disease states remains unclear.
Tjardo Maarseveen +24 more
wiley +1 more source
A novel adaptive quasi-Newton-type update and its global convergence without Lipschitz condition for constrained system of nonlinear monotone equations. [PDF]
Ahmed K +7 more
europepmc +1 more source
Global convergence on the bioethics of surgical implants. [PDF]
Garcia A, Monlezun DJ.
europepmc +1 more source
TECHNOLOGICAL CATCH-UP OR NEOCLASSICAL CONVERGENCE? IDENTIFYING THE CHANNELS OF CONVERGENCE FOR ITALIAN REGIONS [PDF]
We investigate whether Italian regions have converged in terms of output per worker because of physical capital accumulation, human capital accumulation or thanks to technological catch-up.
Vincenzo Scoppa
core
A Q‐Learning Algorithm to Solve the Two‐Player Zero‐Sum Game Problem for Nonlinear Systems
A Q‐learning algorithm to solve the two‐player zero‐sum game problem for nonlinear systems. ABSTRACT This paper deals with the two‐player zero‐sum game problem, which is a bounded L2$$ {L}_2 $$‐gain robust control problem. Finding an analytical solution to the complex Hamilton‐Jacobi‐Issacs (HJI) equation is a challenging task.
Afreen Islam +2 more
wiley +1 more source
Strengthening the Use of International Collaborative Regulatory Assessments and Regulatory Alignment- Implications for Global Convergence. [PDF]
Skerritt JH, Mayer M, Francer J.
europepmc +1 more source

