Results 111 to 120 of about 2,707,305 (304)
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Drugs in R&D, 2019 Background and Objective Given that a high intrapatient variability (IPV) of tacrolimus whole blood concentration increases the risk for a poor kidney transplant outcome, some experts advocate routine IPV monitoring for detection of high-risk patients ...
Janet Kim +5 more
doaj +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Getting to Net-Zero Emissions: Lessons from Latin America and the Caribbean (Executive Summary)
, 2019 All Latin American and Caribbean countries have ratified the Paris Agreement, which aims to limit global warming to between 1.5C and 2C above pre-industrial levels.
Inter-American Development Bank
core +1 more source
Delivering Climate Agenda for LAC: IDB Group Actions to 2020 [PDF]
, 2017 Climate change presents challenges to ensuring global sustainable and inclusive development. The United Nations Framework Convention on Climate Change (UNFCCC) Paris Agreement and the new Sustainable Development Goals (SDGs) reflect an unprecedented ...
Inter-American Development Bank
core +1 more source
FEBS Letters, EarlyView.Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil +4 more
wiley +1 more source
Inter-American Development Bank Sustainability Report 2017
, 2018 The geographic location of the Latin America and the Caribbean region makes it susceptible to natural disasters, including hurricanes, landslides, droughts, and earthquakes.
Inter-American Development Bank
core +1 more source
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Global Microscope on the Microfinance Business Environment 2011 [PDF]
, 2011 This report outlines the findings of the Economist Intelligence Unit\u27s in-depth analysis of the microfinance business environment in 55 countries.
Inter-American Development Bank
core +1 more source