Results 81 to 90 of about 282,128 (301)
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley +1 more source
Neurodegeneration with brain iron accumulation
Annals of Indian Academy of Neurology, 2019 The term NBIA encompasses a heterogeneous group of inherited disorders characterized clinically by progressive extra pyramidal syndrome and pathologically by excessive iron deposition in brain, primarily affecting the basal ganglia (globus pallidus ...
Amit Batla, Chandana Gaddipati
doaj +1 more source
Elicited imitation as a window into developmental stages [PDF]
, 2019 In the second language acquisition literature, data of naturally occurring language use are considered the most ideal data to make statements about second-language (L2) development.
Baten, Kristof, Cornillie, Frederik
core +2 more sources
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
Creating a Development-Oriented Social, Movement and Language Skills Program: Investigating its Effectiveness on Improving the Developmental Indicators of Children with Global Developmental Delay [PDF]
پژوهشهای کاربردی روانشناختیThe objective of this study was to evaluate the efficacy of the development-oriented social, movement, and language skills program in enhancing the developmental indicators of children with Global Developmental Delay (GDD). The research design is a mixed-
Masoumeh Zabeti Arani +3 more
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Behavior Problems in Toddlers With and Without Developmental Delays: Comparison of Treatment Outcomes [PDF]
, 2009 The purpose of this study is to examine the effectiveness of an in-home parent management program for toddlers with behavior problems and developmental delays by comparing outcomes for a group of toddlers with developmental delays (n = 27) and a group of
Carrasco, Jennifer M +3 more
core +1 more source
Screening for Intellectual Disability in Children: A Review of the Literature [PDF]
, 2011 BACKGROUND: Early identification of possible intellectual disability can help children and families access appropriate services and support more quickly. There has been an increasing interest in the use of screening tools for this purpose.
McKenzie, Karen, Megson, Paula
core +1 more source
Diversity and complexity in neural organoids
FEBS Letters, EarlyView.Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley +1 more source
Frontiers in GeneticsCTNNB1, which encodes β-catenin, plays an essential role in the Wnt signaling pathway and regulates cellular homeostasis. Mutations in this gene can lead to neurodevelopmental disorder with spastic diplegia and visual defects (NEDSDV).
Eojin Lee +2 more
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Molecular Genetics & Genomic Medicine, 2019 Background Profiling the entire genome at base pair resolution in a single test offers novel insights into disease by means of dissection of genetic contributors to phenotypic features.
Maja Tarailo‐Graovac +12 more
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