Results 101 to 110 of about 7,959,436 (371)
Cyclic nucleotide signaling as a drug target in retinitis pigmentosa
FEBS Letters, EarlyView.Disruptions in cGMP and cAMP signaling can contribute to retinal dysfunction and photoreceptor loss in retinitis pigmentosa. This perspective examines the mechanisms and evaluates emerging evidence on targeting these pathways as a potential therapeutic strategy to slow or prevent retinal degeneration.
Katri Vainionpää +2 more
wiley +1 more source
, 2015 This paper is concerned with degenerate chemotaxis-Navier-Stokes systems with position-dependent sensitivity on a two dimensional bounded domain.
Sachiko Ishida
semanticscholar +1 more source
Global existence of weak solutions to the three-dimensional Prandtl equations with A special structure [PDF]
, 2015 The global existence of weak solutions to the three space dimensional Prandtl equations is studied under some constraint on its structure. This is a continuation of our recent study on the local existence of classical solutions with the same structure ...
Cheng-Jie Liu, Ya-Guang Wang, Tong Yang
semanticscholar +1 more source
Cell‐free DNA aneuploidy score as a dynamic early response marker in prostate cancer
Molecular Oncology, EarlyView.mFast‐SeqS‐based genome‐wide aneuploidy scores are concordant with aneuploidy scores obtained by whole genome sequencing from tumor tissue and can predict response to ARSI treatment at baseline and, at an early time point, to ARSI and taxanes. This assay can be easily performed at low cost and requires little input of cfDNA. Cell‐free circulating tumor
Khrystany T. Isebia +17 more
wiley +1 more source
Molecular Oncology, EarlyView.MET variants in the N‐lobe of the kinase domain, found in hereditary papillary renal cell carcinoma, require ligand stimulation to promote cell transformation, in contrast to other RTK variants. This suggests that HGF expression in the microenvironment is important for tumor growth in such patients. Their sensitivity to MET inhibitors opens the way for
Célia Guérin +14 more
wiley +1 more source
Electronic Journal of Differential Equations, 2002 Most publications on reaction-diffusion systems of $m$ components ($mgeq 2$) impose $m$ inequalities to the reaction terms, to prove existence of global solutions (see Martin and Pierre [10 ] and Hollis [4]).
Said Kouachi
doaj
Peripheral blood proteome biomarkers distinguish immunosuppressive features of cancer progression
Molecular Oncology, EarlyView.Immune status significantly influences cancer progression. This study used plasma proteomics to analyze benign 67NR and malignant 4T1 breast tumor models at early and late tumor stages. Immune‐related proteins–osteopontin (Spp1), lactotransferrin (Ltf), calreticulin (Calr) and peroxiredoxin 2 (Prdx2)–were associated with systemic myeloid‐derived ...
Yeon Ji Park +6 more
wiley +1 more source
The Global Existence Problem in General Relativity [PDF]
, 2004 We survey some known facts and open questions concerning the global properties of 3+1 dimensional spacetimes containing a compact Cauchy surface. We consider spacetimes with an $\ell$-dimensional Lie algebra of space-like Killing fields. For each $\ell \leq 3$, we give some basic results and conjectures on global existence and cosmic censorship.
openaire +3 more sources
Blow-up for p-Laplacian parabolic equations
Electronic Journal of Differential Equations, 2003 In this article we give a complete picture of the blow-up criteria for weak solutions of the Dirichlet problem $$ u_t= abla(| abla u|^{p-2} abla u)+lambda |u|^{q-2}u,quad hbox{in } Omega_T, $$ where $p>1$.
Yuxiang Li, Chunhong Xie
doaj
, 2015 This paper is concerned with the parabolic-elliptic Keller-Segel system with signal-dependent sensitivity $\chi(v)$, \begin{align*} \begin{cases} u_t=\Delta u - \nabla \cdot ( u \nabla \chi(v)) &\mathrm{in}\ \Omega\times(0,\infty), \\ 0=\Delta ...
Kentarou Fujie, T. Senba
semanticscholar +1 more source