Results 101 to 110 of about 9,026,361 (324)

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Global Existence, General Decay, and Blow Up of the Solution to the Coupled p-Biharmonic Equation of Hyperbolic Type with Degenerate Damping Terms

Mathematics
In this work, we study a nonlinear system of p-Biharmonic hyperbolic equations with degenerate damping and source terms in a bounded domain. Under appropriate assumptions on the initial data and the damping terms, we establish the global existence of ...
Nouri Boumaza, Billel Gheraibia, Hongwei Zhang, Zayd Hajjej   +3 more
doaj   +1 more source

Global Existence and Fixed-Time Synchronization of a Hyperchaotic Financial System Governed by Semi-Linear Parabolic Partial Differential Equations Equipped with the Homogeneous Neumann Boundary Condition. [PDF]

Entropy (Basel), 2023
Wang C, Zhao X, Zhang Y, Lv Z.
europepmc   +1 more source

Global existence of near-affine solutions to the compressible Euler equations

, 2019
We establish global existence of solutions to the compressible Euler equations, in the case that a finite volume of ideal gas expands into vacuum. Vacuum states can occur with either smooth or singular sound speed, the latter corresponding to the so ...
Shkoller, Steve, Sideris, Thomas C.
core  

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Global existence of semilinear system of Klein-Gordon equations in anti-de Sitter spacetime

Demonstratio Mathematica
In this article, we consider the initial value problem for a system of Klein-Gordon equations in anti-de Sitter spacetime. We assume that the mass matrix is diagonalizable with positive eigenvalues.
Yazıcı Muhammet
doaj   +1 more source

On the Global Existence and Boundedness of Solutions of a Certain Integro-Vector Differential Equation of Second Order

Journal of Mathematical and Fundamental Sciences, 2018
In this paper, we consider a nonlinear integro-vector differential equation of the second order. We establish sufficient conditions that guarantee the global existence and boundedness of solutions of the equation considered. The method of proof involves
Cemil Tunc, Timur Ayhan
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

FEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel, Carl P. O. Helmer, Shani Zev, Ronja Driller, Emily Buhr, Markus Reinbold, Renana Schwartz, Gabriel Foley, Mikael Boden, Daniel Garbe, Gerhard Schenk, Dan Thomas Major, Bernhard Loll, Thomas Brück   +13 more
wiley   +1 more source

Asymptotic Analysis and Blow-Up of Solution for a q-Kirchhoff-Type Equation with Nonlinear Boundary Damping and Source Terms with Variable Exponents

Mathematics
In this study, we examine a q-Kirchhoff-type equation defined on a bounded domain, incorporating nonlinear boundary damping and source terms with variable exponents. Assuming appropriate conditions on the initial data and the variable exponent functions,
Nouri Boumaza, Billel Gheraibia, Zayd Hajjej, Hongwei Zhang, Said Mesloub   +4 more
doaj   +1 more source