Results 111 to 120 of about 7,959,436 (371)

Targeting the MDM2‐MDM4 interaction interface reveals an otherwise therapeutically active wild‐type p53 in colorectal cancer

Molecular Oncology, EarlyView.
This study investigates an alternative approach to reactivating the oncosuppressor p53 in cancer. A short peptide targeting the association of the two p53 inhibitors, MDM2 and MDM4, induces an otherwise therapeutically active p53 with unique features that promote cell death and potentially reduce toxicity towards proliferating nontumor cells.
Sonia Valentini, Giada Mele, Marika Attili, Maria Rita Assenza, Fulvio Saccoccia, Francesca Sardina, Cinzia Rinaldo, Roberto Massari, Nicola Tirelli, Alfredo Pontecorvi, Fabiola Moretti   +10 more
wiley   +1 more source

Existence of global solutions of elliptic systems

Journal of Mathematical Analysis and Applications, 2004
AbstractWe study existence of entire solutions of elliptic systems whose prototype is given by div|u|γ|∇u|m−2∇u−γm|u|γ−2u|∇u|m=|u|p−2u,u:Rn→RN, with m>1, γ∈R, p>1. In particular, we prove that, if γ⩾p−m, the system above admits a one parameter family of nontrivial entire radial solutions, u=u(|x|), such that lim|x|→∞|u(|x|)|=∞.
openaire   +4 more sources

Blow-up of radially symmetric solutions of a non-local problem modelling Ohmic heating

Electronic Journal of Differential Equations, 2002
We consider a non-local initial boundary-value problem for the equation $$ u_t=Delta u+lambda f(u)/Big(int_{Omega}f(u),dxBig)^2 ,quad x in Omega subset mathbb{R}^2 ,,;t>0, $$ where $u$ represents a temperature and $f$ is a positive and decreasing ...
Dimitrios E. Tzanetis
doaj  

Elucidating prognostic significance of purine metabolism in colorectal cancer through integrating data from transcriptomic, immunohistochemical, and single‐cell RNA sequencing analysis

Molecular Oncology, EarlyView.
Low expression of five purine metabolism‐related genes (ADSL, APRT, ADCY3, NME3, NME6) was correlated with poor survival in colorectal cancer. Immunohistochemistry analysis showed that low NME3 (early stage) and low ADSL/NME6 (late stage) levels were associated with high risk.
Sungyeon Kim, Myunghee Kang, Soyeon Jeong, Jisup Kim, Kyoung Oh Kim, Won‐Suk Lee, Jeong‐Heum Baek, Jung Ho Kim, Seungyoon Nam   +8 more
wiley   +1 more source

Highly multiplexed digital PCR assay for simultaneous quantification of variant allele frequencies and copy number alterations of KRAS and GNAS in pancreatic cancer precursors

Molecular Oncology, EarlyView.
Combining melting curve analysis enhances the multiplexing capability of digital PCR. Here, we developed a 14‐plex assay to simultaneously measure single nucleotide mutations and amplifications of KRAS and GNAS, which are common driver genes in pancreatic cancer precursors. This assay accurately quantified variant allele frequencies in clinical samples
Junko Tanaka, Tatsuo Nakagawa, Yusuke Ono, Yoshio Kamura, Takeshi Ishida, Hidemasa Kawabata, Kenji Takahashi, Hiroki Sato, Andrew S. Liss, Yusuke Mizukami, Takahide Yokoi   +10 more
wiley   +1 more source

The global classical solution to compressible Euler system with velocity alignment

AIMS Mathematics, 2020
In this paper, the compressible Euler system with velocity alignment and damping is considered, where the influence matrix of velocity alignment is not positive definite. Sound speed is used to reformulate the system into symmetric hyperbolic type.
Lining Tong, Li Chen, Simone Göttlich, Shu Wang   +3 more
doaj   +1 more source

Exploration of heterogeneity and recurrence signatures in hepatocellular carcinoma

Molecular Oncology, EarlyView.
This study leveraged public datasets and integrative bioinformatic analysis to dissect malignant cell heterogeneity between relapsed and primary HCC, focusing on intercellular communication, differentiation status, metabolic activity, and transcriptomic profiles.
Wen‐Jing Wu, Jianchao Wang, Fuqing Chen, Xuefeng Wang, Bin Lan, Ruyi Fu, Hong Wen, Fangfang Chen, Wei Hong, Tian‐Yu Tang, Ying He, Gang Chen, Jianyin Zhou, Hai‐Long Piao, Di Chen, Shu‐Yong Lin   +15 more
wiley   +1 more source

Global Existence and Nonexistence in a System of Petrovsky [PDF]

Journal of Mathematical Analysis and Applications, 2002
AbstractIn this paper we consider the nonlinearly damped semilinear Petrovsky equationutt+Δ2u+aut|ut|m−2=bu|u|p−2in a bounded domain, where a,b>0. We prove the existence of a local weak solution and show that this solution blows up in finite time if p>m and the energy is negative. We also show that the solution is global if m≥p.
openaire   +1 more source

Comparing self‐reported race and genetic ancestry for identifying potential differentially methylated sites in endometrial cancer: insights from African ancestry proportions using machine learning models

Molecular Oncology, EarlyView.
Integrating ancestry, differential methylation analysis, and machine learning, we identified robust epigenetic signature genes (ESGs) and Core‐ESGs in Black and White women with endometrial cancer. Core‐ESGs (namely APOBEC1 and PLEKHG5) methylation levels were significantly associated with survival, with tumors from high African ancestry (THA) showing ...
Huma Asif, J. Julie Kim
wiley   +1 more source

The Existence of the State in the Process of Globalization

International Journal of Social Science Humanity & Management Research
The article aims to systematically present the transformation from the management function to the service function, from the social production function to the function of maintaining the value of the domestic currency. To achieve this purpose, the article's content approaches the methodology of human philosophy and social philosophy while using ...
openaire   +1 more source