Results 141 to 150 of about 7,959,436 (371)

Evaluation of KRAS and NRAS mutations in metastatic colorectal cancer: an 8‐year study of 10 754 patients in Turkey

open access: yesMolecular Oncology, EarlyView.
This nationwide study evaluated KRAS and NRAS mutations in 10 754 Turkish patients with metastatic colorectal cancer. The results revealed a mutation frequency of 51.1%, with 46.6% having KRAS mutations, 4.5% having NRAS mutations, and 48.5% being wild‐type for both.
Gozde Kavgaci   +6 more
wiley   +1 more source

A note on the global existence and boundedness of an N-dimensional parabolic-elliptic predator-prey system with indirect pursuit-evasion interaction

open access: yesOpen Mathematics
We investigate the two-species chemotaxis predator-prey system given by the following system: ut=Δu−χ∇⋅(u∇w)+u(λ1−μ1ur1−1+av),x∈Ω,t>0,vt=Δv+ξ∇⋅(v∇z)+v(λ2−μ2vr2−1−bu),x∈Ω,t>0,0=Δw−w+v,x∈Ω,t>0,0=Δz−z+u,x∈Ω,t>0,\left\{\begin{array}{ll}{u}_{t}=\Delta u-\chi \
Liu Ling
doaj   +1 more source

Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer

open access: yesMolecular Oncology, EarlyView.
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren   +16 more
wiley   +1 more source

Nonlinear heat equation with viscoelastic term: Global existence and blowup in finite time

open access: yesDemonstratio Mathematica
In this study, we investigate a nonlinear heat equation incorporating both a viscoelastic term and a reaction-diffusion term that depends on space-time variables.
Vu Ngo Tran, Dung Dao Bao
doaj   +1 more source

Comprehensive omics‐based classification system in adult patients with B‐cell acute lymphoblastic leukemia

open access: yesMolecular Oncology, EarlyView.
The COMBAT classification system, developed through multi‐omics integration, stratifies adult patients with B‐cell acute lymphoblastic leukemia(B‐ALL) into three molecular subtypes with distinct surface antigen patterns, immune landscape, methylation patterns, biological pathways and prognosis.
Yang Song   +11 more
wiley   +1 more source

Local and Global Solvability for Advection-Diffusion Equation on an Evolving Surface with a Boundary

open access: yes, 2019
This paper considers the existence of local and global-in-time strong solutions to the advection-diffusion equation with variable coefficients on an evolving surface with a boundary.
Koba, Hajime
core  

Circulating tumor DNA monitoring and blood tumor mutational burden in patients with metastatic solid tumors treated with atezolizumab

open access: yesMolecular Oncology, EarlyView.
In patients treated with atezolizumab as a part of the MyPathway (NCT02091141) trial, pre‐treatment ctDNA tumor fraction at high levels was associated with poor outcomes (radiographic response, progression‐free survival, and overall survival) but better sensitivity for blood tumor mutational burden (bTMB).
Charles Swanton   +17 more
wiley   +1 more source

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