Results 161 to 170 of about 6,658,638 (311)

CDC Center for Global Health (CGH) 2016 annual report [PDF]

open access: yes
CGH coordinates global health activities across CDC. CGH is made up of four divisions: Division of Global Health Protection (DGHP), Division of Global HIV & TB (DGHT), Division of Parasitic Diseases and Malaria (DPDM), and Global Immunization Division ...

core  

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

open access: yesMolecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee   +3 more
wiley   +1 more source

CDC Center for Global Health 2017 annual report [PDF]

open access: yes
CS289084-AXPublication date from document properties.CGH_Annual-Report_2017-h.pdfAbout the Center for Global Health (CGH): Background and Organizational -- Structure -- Snapshot of CGH Accomplishments in 2017 -- Division of Global Health Protection (DGHP)

core  

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

open access: yesMolecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

CDC global health strategy (2012-2015) : 2012 annual progress report [PDF]

open access: yes
The vision of CDC\u2019s global heath strategy is a world where people live healthier, safer, and longer lives through science, policy, partnership, and evidence-based public health action.

core  

Mechanisms and therapeutic opportunities of the ribotoxic stress response in cancer

open access: yesMolecular Oncology, EarlyView.
Cancer cells' high translational demand creates opportunities to therapeutically target ribosome function. Ribosome stalling and collisions activate ZAKα and the ribotoxic stress response (RSR), which can trigger rapid, p53‐independent apoptosis in cancer.
Anastassiya Kim   +7 more
wiley   +1 more source

Critical parameter equations for degenerate parabolic equations coupled via nonlinear boundary flux

open access: yesBoundary Value Problems, 2011
This paper deals with the critical parameter equations for a degenerate parabolic system coupled via nonlinear boundary flux. By constructing the self-similar supersolution and subsolution, we obtain the critical global existence parameter equation.
Xu Si, Song Zifen
doaj  

El ingeniero global en el desarrollo humano y sostenible

open access: yes
Obra formada per: Bloque A "El ingeniero global" (Vol. 1. La necesidad del ingeniero global. Vol. 2. Los elementos clave para afrontar la dimensión global de la ingeniería. Vol. 3.
Global Dimension in Engineering Education
core  

Profiling neoadjuvant therapy response in rectal cancer using meta‐analysis of publicly available transcriptomic RNA‐seq datasets

open access: yesMolecular Oncology, EarlyView.
This study integrates publicly available transcriptomic datasets to identify molecular signatures associated with response to neoadjuvant chemoradiotherapy in locally advanced rectal cancer. By analyzing a combination of multiple cohorts with bioinformatics approaches, we reveal biological pathways and immune‐related features that may improve ...
Aleksandra Stanojevic   +10 more
wiley   +1 more source

Gut microbiota alterations in patients with non‐small‐cell lung cancer undergoing chemoradiotherapy

open access: yesMolecular Oncology, EarlyView.
We investigated the impact of concurrent chemoradiotherapy (CRT) on the gut microbiota in patients with locally advanced non‐small‐cell lung cancer. Overall gut microbiota composition remained largely stable throughout CRT while antibiotic exposure may influence microbial diversity.
Hanne Marte Nymoen   +19 more
wiley   +1 more source

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