Results 141 to 150 of about 6,658,638 (311)

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

Molecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller, Janina Müller, Efstathios‐Iason Vlachavas, Lukas Beumers, Lena Fleischhacker, Sara Burmester, Angelika Wörner, Sabine Karolus, Dominic Helm, Cindy Körner, Stefan Wiemann   +10 more
wiley   +1 more source

The National Global Change Research Plan 2012-2021: A Triennial Update

, 2017
This report is the third triennial update of the National Global Change Research Plan based on scientific research from 13 Federal agencies. The purpose of each update is to "advance science, inform decisions, conduct...assessments" and communicate ...
U.S. Global Change Research Program
core  

Global Warming: A Titanic Problem [PDF]

, 2012
Global warming is one of those areas of science that gets all sorts of people exited Though a few ask for more and more evidence that global environmental change is taking place most accept that human activities are causing changes quite unlike any ...
Dr. Md. Zulfequar Ahmad Khan
core  

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Global Existence and Decay Estimates for a Viscoelastic Petrovsky–Kirchhoff-Type Equation with a Delay Term

Axioms
In this paper, we consider a viscoelastic Kirchhoff equation with a delay term in the internal feedback. By using the Faedo–Galerkin approximation method, we prove the well posedness of the global solutions.
Noureddine Sebih, Abdelhamid Mohammed Djaouti, Chafi Boudekhil, Ashraf Al-Quran   +3 more
doaj   +1 more source

Global existence of Dirac-wave maps with curvature term on expanding spacetimes. [PDF]

Calc Var Partial Differ Equ, 2018
Branding V, Kröncke K.
europepmc   +1 more source

Almost Global Existence for Kirchhoff Equations Around Global Solutions

SIAM Journal on Mathematical Analysis
26 ...
Ghisi, Marina, Gobbino, Massimo
openaire   +5 more sources

Equilibria Existence in Regular Discontinuous Games [PDF]

Many conditions have been introduced to weaken the continuity re- quirements for equilibrium existence in games. We introduce a new con- dition, called regularity, that is simple and easy to verify.
Luciano I. de Castro
core  

In vitro and in silico modelling of ROS1‐positive non‐small cell lung cancer reveals fusion‐dependent tyrosine kinase inhibitor responses

Molecular Oncology, EarlyView.
Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq, Marc Terrones, Felicia Rodrigues Fortes, Anne Schepers, Alessia Denis, Christophe Deben, Ken Op de Beeck, Guy Van Camp, Geert Vandeweyer   +8 more
wiley   +1 more source

Global existence and blow-up results for p-Laplacian parabolic problems under nonlinear boundary conditions. [PDF]

J Inequal Appl, 2018
Ding J.
europepmc   +1 more source