Results 51 to 60 of about 6,210,205 (314)

Global existence of weak solutions to the three-dimensional Prandtl equations with A special structure [PDF]

open access: yes, 2015
The global existence of weak solutions to the three space dimensional Prandtl equations is studied under some constraint on its structure. This is a continuation of our recent study on the local existence of classical solutions with the same structure ...
Cheng-Jie Liu, Ya-Guang Wang, Tong Yang
semanticscholar   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Global Existence and Nonexistence in a System of Petrovsky

open access: yesJournal of Mathematical Analysis and Applications, 2002
The author considers the problem \[ \begin{cases} u_{tt}+\Delta^2u+au_t|u_t|^{m-2}=bu|u|^{p-2}, &x\in \Omega\;\text{ and } t>0,\\ u(x,t)=\partial_\nu u(x,t)=0, &x\in \partial\Omega\;\text{ and } t\geq 0,\\ u(x,0)=\phi(x), u_t(x,0)=\psi(x), &x\in\Omega,\end{cases}\tag{1} \] where \(\Omega\) is a bounded domain of \({\mathbb{R}}^n\) with smooth boundary \
openaire   +2 more sources

The Global Existence Problem in General Relativity [PDF]

open access: yes, 2004
We survey some known facts and open questions concerning the global properties of 3+1 dimensional spacetimes containing a compact Cauchy surface. We consider spacetimes with an $\ell$-dimensional Lie algebra of space-like Killing fields. For each $\ell \leq 3$, we give some basic results and conjectures on global existence and cosmic censorship.
openaire   +2 more sources

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

open access: yesMolecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou   +5 more
wiley   +1 more source

Global existence and boundedness for chemotaxis-Navier-Stokes systems with position-dependent sensitivity in 2D bounded domains

open access: yes, 2015
This paper is concerned with degenerate chemotaxis-Navier-Stokes systems with position-dependent sensitivity on a two dimensional bounded domain.
Sachiko Ishida
semanticscholar   +1 more source

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

open access: yesMolecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan   +9 more
wiley   +1 more source

Bridging the gap: Multi‐stakeholder perspectives of molecular diagnostics in oncology

open access: yesMolecular Oncology, EarlyView.
Although molecular diagnostics is transforming cancer care, implementing novel technologies remains challenging. This study identifies unmet needs and technology requirements through a two‐step stakeholder involvement. Liquid biopsies for monitoring applications and predictive biomarker testing emerge as key unmet needs. Technology requirements vary by
Jorine Arnouts   +8 more
wiley   +1 more source

Global existence of nonlinear elastic waves [PDF]

open access: yesInventiones Mathematicae, 2000
zbMATH Open Web Interface contents unavailable due to conflicting licenses.
openaire   +4 more sources

Emerging role of ARHGAP29 in melanoma cell phenotype switching

open access: yesMolecular Oncology, EarlyView.
This study gives first insights into the role of ARHGAP29 in malignant melanoma. ARHGAP29 was revealed to be connected to tumor cell plasticity, promoting a mesenchymal‐like, invasive phenotype and driving tumor progression. Further, it modulates cell spreading by influencing RhoA/ROCK signaling and affects SMAD2 activity. Rho GTPase‐activating protein
Beatrice Charlotte Tröster   +3 more
wiley   +1 more source

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