Results 81 to 90 of about 6,843,871 (313)

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

open access: yesFEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Global existence and blow-up of generalized self-similar solutions for a space-fractional diffusion equation with mixed conditions

open access: yesAnnales Universitatis Paedagogicae Cracoviensis: Studia Mathematica, 2021
This paper investigates the problem of the existence and uniqueness of solutions under the generalized self-similar forms to the space-fractional diffusion equation.
Farid Nouioua, Bilal Basti
doaj  

Blow-up and global existence for nonlinear reaction-diffusion equations under Neumann boundary conditions

open access: yesJournal of Inequalities and Applications, 2016
In this paper, we study the blow-up and global solutions of the following nonlinear reaction-diffusion equations under Neumann boundary conditions: { ( g ( u ) ) t = ∇ ⋅ ( a ( u ) b ( x ) ∇ u ) + f ( x , u ) in  D × ( 0 , T ) , ∂ u ∂ n = 0 on  ∂ D × ( 0 ,
Juntang Ding
doaj   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

Research on the Properties of Solutions to Fourth-Order Pseudo-Parabolic Equations with Nonlocal Sources

open access: yesMathematics
This paper investigates the initial-boundary value problem for a fourth-order pseudo-parabolic equation with a nonlocal source: ut+Δ2u−Δut=uq−1u−1Ω∫Ωuq−1udx.
Chunxiao Yang, Wanqing Li
doaj   +1 more source

Global existence of solutions for a fractional Caputo nonlocal thermistor problem

open access: yesAdvances in Difference Equations, 2017
We begin by proving a local existence result for a fractional Caputo nonlocal thermistor problem. Then additional existence and continuation theorems are obtained, ensuring global existence of solutions.
Moulay Rchid Sidi Ammi   +2 more
doaj   +1 more source

Global existence for Maxwell–Bloch systems

open access: yesJournal of Differential Equations, 2005
The author proves an existence and uniqueness result for the energy solution of the Maxwell-Bloch system with arbitrary initial vector in \(L^2(\mathbb R^3)\times L^2(\mathbb R^3)\times (L^2\cap L^\infty)(\mathbb R^3)\) verifying the conservation of current and charge.
openaire   +2 more sources

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

open access: yesFEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman   +2 more
wiley   +1 more source

In situ molecular organization and heterogeneity of the Legionella Dot/Icm T4SS

open access: yesFEBS Letters, EarlyView.
We present a nearly complete in situ model of the Legionella Dot/Icm type IV secretion system, revealing its central secretion channel and identifying new components. Using cryo‐electron tomography with AI‐based modeling, our work highlights the structure, variability, and mechanism of this complex nanomachine, advancing understanding of bacterial ...
Przemysław Dutka   +11 more
wiley   +1 more source

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