Results 141 to 150 of about 6,939,271 (302)

Structures of mycobacterial 3‐methylcrotonyl‐CoA carboxylase reveal carrier‐domain translocation between catalytic sites

open access: yesFEBS Letters, EarlyView.
Mycobacterial 3‐methylcrotonyl‐CoA carboxylase uses a mobile biotin‐carrying domain to shuttle a carboxyl group between two catalytic sites, enabling carboxylation of 3‐methylcrotonyl‐CoA during leucine breakdown. Cryo‐electron microscopy captures the carrier at both sites and reveals an inward loop movement that may prevent futile rebinding to the ...
Ajit Yadav   +2 more
wiley   +1 more source

GLNet: global-local feature network for wheat leaf disease image classification

open access: yesFrontiers in Plant Science
Addressing the issues with insufficient multi-scale feature perception and incomplete understanding of global information in traditional convolutional neural networks for image classification of wheat leaf disease, this paper proposes a global local ...
Shangze Li   +5 more
doaj   +1 more source

MF-Net: Automated Muscle Fiber Segmentation From Immunofluorescence Images Using a Local-Global Feature Fusion Network. [PDF]

open access: yesJ Digit Imaging, 2023
Du G   +8 more
europepmc   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

Prospecting the protein design landscape

open access: yesFEBS Letters, EarlyView.
This review outlines the current state of various protein design approaches. We discuss the current possibilities enabled by recently released tools, highlight future avenues to pursue in protein design, and underscore the crucial role of key databases and resources for successful protein design workflows.
Jakob R. Riccabona   +4 more
wiley   +1 more source

Feature Extraction and Duplicate Detection for Text Mining: A Survey [PDF]

open access: yes, 2016
Text mining, also known as Intelligent Text Analysis is an important research area. It is very difficult to focus on the most appropriate information due to the high dimensionality of data.
Venugopal K R, Ramya R S
core  

Internet marketing global features

open access: yesMarketing (Beograd. 1991), 2005
Business environment incessantly bringing a yard of a new challenges to market entities. One of the greatest challenges that companies faced during the last couple of decades was development of information systems as well as a large scale usage of world's greatest computer network - Internet - no matter how big they were or what their activities ...
Rakita Branko, Mitić Sanja
openaire   +1 more source

Global-feature of autoimmune glomerulonephritis using proteomic analysis of laser capture microdissected glomeruli. [PDF]

open access: yesFront Immunol, 2023
Dong J   +11 more
europepmc   +1 more source

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