Results 111 to 120 of about 3,970,331 (279)

A fine-grained human facial key feature extraction and fusion method for emotion recognition

open access: yesScientific Reports
Emotion, a fundamental mapping of human responses to external stimuli, has been extensively studied in human–computer interaction, particularly in areas such as intelligent cockpits and systems.
Shiwei Li   +4 more
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

open access: yesFEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto   +3 more
wiley   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

open access: yesFEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa   +5 more
wiley   +1 more source

Dual-Regularized Feature Selection for Class-Specific and Global Feature Associations

open access: yesEntropy
Understanding feature associations is vital for selecting the most informative features. Existing methods primarily focus on global feature associations, which capture overall relationships across all samples. However, they often overlook class-specific feature interactions, which are essential for capturing locality features that may only be ...
Chenchen Wang   +4 more
openaire   +3 more sources

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

open access: yesFEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Face Recognition Using Local and Global Features

open access: yesEURASIP Journal on Advances in Signal Processing, 2004
The combining classifier approach has proved to be a proper way for improving recognition performance in the last two decades. This paper proposes to combine local and global facial features for face recognition.
Lai JH   +3 more
doaj   +1 more source

A methionine‐lined active site governs carbocation stabilization and product specificity in a bacterial terpene synthase

open access: yesFEBS Letters, EarlyView.
This study reveals a unique active site enriched in methionine residues and demonstrates that these residues play a critical role by stabilizing carbocation intermediates through novel sulfur–cation interactions. Structure‐guided mutagenesis further revealed variants with significantly altered product profiles, enhancing pseudopterosin formation. These
Marion Ringel   +13 more
wiley   +1 more source

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