Results 211 to 220 of about 5,945,819 (313)

Chameleon sequences reveal structural effects in proteins representing micelle‐like distribution of hydrophobicity

FEBS Open Bio, EarlyView.
Amino acids sequence of two different proteins with the same sequence (chameleon sequence—black boxes) represent in 3D structure of the proteins different secondary structures: HHHH—helical and BBB—Beta‐structural. The chains folded in water environment adopt different III‐order structures in which the chameleon fragments appear to adopt similar status
Irena Roterman, Katarzyna Stapor, Leszek Konieczny, Krzysztof Gądek, Piotr Nowakowski   +4 more
wiley   +1 more source

Securing independence in global health oversight-the OPEN framework. [PDF]

Health Aff Sch
Schwalbe N, Hannon E, Lehtimaki S, Wahl B.   +3 more
europepmc   +1 more source

Analysing the significance of small conformational changes and low occupancy states in serial crystallographic data

FEBS Open Bio, EarlyView.
This protocol paper outlines methods to establish the success of a time‐resolved serial crystallographic experiment, by means of statistical analysis of timepoint data in reciprocal space and models in real space. We show how to amplify the signal from excited states to visualise structural changes in successful experiments.
Jake Hill, Yelyzaveta Pulnova, Elke De Zitter, Helen M. Ginn, Briony A. Yorke   +4 more
wiley   +1 more source

The Architecture of Decolonial Partnerships in University Global Health Program Development. [PDF]

Ann Glob Health
Crane S, Moralez AH, Diaz WF, Waldman B, Ansell D, Hernandez EM, Vlaming J, Dressel K, Young S, Kusinitz Z.   +9 more
europepmc   +1 more source

Screening and epitope characterization of Nidogen‐2‐specific nanobodies

FEBS Open Bio, EarlyView.
Camel immunization and phage display were employed to generate high‐affinity VHH nanobodies against Nidogen‐2. After library construction, biopanning, ELISA screening, sequencing, and recombinant expression, selected nanobodies were purified and characterized, leading to the preliminary exploration of a nanobody‐based sandwich ELISA for specific ...
Jianchuan Wen, Qianqian Cui, Zhongyun Lan, Yingjun Wang, Shuaiying Zhao, Wenxuan Feng, Yunfeng Liu, Qiting Huang, Dongna Zhang, Jianfeng Xu   +9 more
wiley   +1 more source

Global health in the face of 'permacrises': why primary health care matters. [PDF]

Prim Health Care Res Dev
Omam LA, Nkengateh AN, Mba CM.
europepmc   +1 more source

Quantitative proteomic analysis reveals different characteristics of bladder cancer cells after exposure to bisphenol A

FEBS Open Bio, EarlyView.
Bisphenol A (BPA), a common chemical in plastics, exerts dual effects on bladder cancer cells: low doses promote growth and migration, while high doses suppress growth and migration. Multi‐omics and bioinformatics reveal BPA acts via MAPK and inflammatory pathways.
Shaomin Niu, Lanlan Li, Wenjuan Jia, Hanzhong Feng, Xiaoquan Yu, Youli Zhao, Fengzhi Yuan, Hui Ding, Junqiang Tian, Yong‐Xing He, Zhiping Wang   +10 more
wiley   +1 more source

Modernizing public health surveillance for global health security leveraging AI. [PDF]

Lancet Reg Health Am
Ogunyemi KO, Shaikh AT, Bashir A, Dixon BE, Warmath D, Toth M, Salim J, Lokossou VK, Teferi F, Baer C, Brown J, Sogbossi LS, Zohra T, Tom-Aba D, Awori AS, Said AH, Chen Y, Antara S, Gebreyes WA, Winter AK, Ali H, Squires N, Kebede S, Asghar RJ, Chungong S, Alemu W, Aïssi MA, Sekandi JN, Wuhib T, Ohuabunwo C, Shen Y, McNabb SJN.   +31 more
europepmc   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Environmental degradation as a recipe for emerging viral diseases: implications for global health. [PDF]

One Health Outlook
Hudu SA, Jimoh AO, Amin-Nordin S, Syed Hassan S.   +3 more
europepmc   +1 more source