Results 51 to 60 of about 887,841 (265)
Reciprocal control of viral infection and phosphoinositide dynamics
FEBS Letters, EarlyView.Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley +1 more source
Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
De la simultanéité en histoire globale
L'Atelier du CRH, 2019 This essay focuses on simultaneity as a discursive figure of global history. The question is rather simple: why does global history sometimes use simultaneities to demonstrate connections?
Adrien Delmas
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Contre une vision diffusionniste de la « naissance de la prison »
Socio, 2020 During the “long” 19th century, the prison became the dominant institution of punishment on a worldwide scale. Focussing on the first half of this period, the article demonstrates that concepts of diffusion, which continue to provide the central model of
Stephan Scheuzger
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FEBS Letters, EarlyView.We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee +3 more
wiley +1 more source
FEBS Letters, EarlyView.We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
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Социология властиThe article discusses the heuristic and methodological potential of historical sociology as one of the most dynamically developing disciplines of modern social and scientific knowledge.
T. A. Dmitriev, O. V. Kildyushov
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FEBS Letters, EarlyView.In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai +9 more
wiley +1 more source
Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
The genealogy of the History teaching for International Relations
Meridiano 47, 2017 This genealogical narrative reflects on how different generations share the same spaces of experiences and converge their horizons of expectations about the place of History in International Relations. The future of teaching History for IR depends on how
Thiago Gehre Galvão, Gunther Mros
doaj